Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

The CRISPR-associated protein Cas9 is an RNA-guided endonuclease that cleaves double-stranded DNAs bearing sequences complementary to a 20-nucleotide segment in the guide RNA(1,2). Cas9 has emerged as a versatile molecular tool for genome editing and gene expression control(3). RNA-guided DNA recogn...

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Detalles Bibliográficos
Autores principales: Anders, Carolin, Niewoehner, Ole, Duerst, Alessia, Jinek, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176945/
https://www.ncbi.nlm.nih.gov/pubmed/25079318
http://dx.doi.org/10.1038/nature13579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176945/
https://www.ncbi.nlm.nih.gov/pubmed/25079318
http://dx.doi.org/10.1038/nature13579

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