Bortezomib Prevents Acute Doxorubicin Ovarian Insult and Follicle Demise, Improving the Fertility Window and Pup Birth Weight in Mice

Increasing numbers of female patients survive cancer, but succumb to primary ovarian insufficiency after chemotherapy. We tested the hypothesis that Bortezomib (Bort) protects ovaries from doxorubicin (DXR) chemotherapy by treating female mice with Bort 1 hour prior to DXR. By preventing DXR accumul...

Descripción completa

Detalles Bibliográficos
Autores principales: Roti Roti, Elon C., Ringelstetter, Ashley K., Kropp, Jenna, Abbott, David H., Salih, Sana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176970/
https://www.ncbi.nlm.nih.gov/pubmed/25251158
http://dx.doi.org/10.1371/journal.pone.0108174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176970/
https://www.ncbi.nlm.nih.gov/pubmed/25251158
http://dx.doi.org/10.1371/journal.pone.0108174

Ejemplares similares