Damage To Dorsolateral Prefrontal Cortex Affects Tradeoffs Between Honesty And Self-Interest

Substantial correlational evidence exists suggesting a critical role for prefrontal regions in honest and dishonest behavior, but causal evidence specifying the nature of this involvement remains absent. Here we show using the lesion method that damage to the human dorsolateral prefrontal cortex (DL...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Lusha, Jenkins, Adrianna C., Set, Eric, Scabini, Donatella, Knight, Robert T., Chiu, Pearl H., King-Casas, Brooks, Hsu, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177007/
https://www.ncbi.nlm.nih.gov/pubmed/25174003
http://dx.doi.org/10.1038/nn.3798
_version_ 1782336705333821440
author Zhu, Lusha
Jenkins, Adrianna C.
Set, Eric
Scabini, Donatella
Knight, Robert T.
Chiu, Pearl H.
King-Casas, Brooks
Hsu, Ming
author_facet Zhu, Lusha
Jenkins, Adrianna C.
Set, Eric
Scabini, Donatella
Knight, Robert T.
Chiu, Pearl H.
King-Casas, Brooks
Hsu, Ming
author_sort Zhu, Lusha
collection PubMed
description Substantial correlational evidence exists suggesting a critical role for prefrontal regions in honest and dishonest behavior, but causal evidence specifying the nature of this involvement remains absent. Here we show using the lesion method that damage to the human dorsolateral prefrontal cortex (DLPFC) decreased the effect of honesty concerns on behavior in economic games that pit honesty motives against self-interest, but did not affect decisions where honesty concerns were absent. These results point to a causal role for DLPFC in enabling honest behavior.
format Online
Article
Text
id pubmed-4177007
institution National Center for Biotechnology Information
language English
publishDate 2014
record_format MEDLINE/PubMed
spelling pubmed-41770072015-04-01 Damage To Dorsolateral Prefrontal Cortex Affects Tradeoffs Between Honesty And Self-Interest Zhu, Lusha Jenkins, Adrianna C. Set, Eric Scabini, Donatella Knight, Robert T. Chiu, Pearl H. King-Casas, Brooks Hsu, Ming Nat Neurosci Article Substantial correlational evidence exists suggesting a critical role for prefrontal regions in honest and dishonest behavior, but causal evidence specifying the nature of this involvement remains absent. Here we show using the lesion method that damage to the human dorsolateral prefrontal cortex (DLPFC) decreased the effect of honesty concerns on behavior in economic games that pit honesty motives against self-interest, but did not affect decisions where honesty concerns were absent. These results point to a causal role for DLPFC in enabling honest behavior. 2014-08-31 2014-10 /pmc/articles/PMC4177007/ /pubmed/25174003 http://dx.doi.org/10.1038/nn.3798 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Zhu, Lusha
Jenkins, Adrianna C.
Set, Eric
Scabini, Donatella
Knight, Robert T.
Chiu, Pearl H.
King-Casas, Brooks
Hsu, Ming
Damage To Dorsolateral Prefrontal Cortex Affects Tradeoffs Between Honesty And Self-Interest
title Damage To Dorsolateral Prefrontal Cortex Affects Tradeoffs Between Honesty And Self-Interest
title_full Damage To Dorsolateral Prefrontal Cortex Affects Tradeoffs Between Honesty And Self-Interest
title_fullStr Damage To Dorsolateral Prefrontal Cortex Affects Tradeoffs Between Honesty And Self-Interest
title_full_unstemmed Damage To Dorsolateral Prefrontal Cortex Affects Tradeoffs Between Honesty And Self-Interest
title_short Damage To Dorsolateral Prefrontal Cortex Affects Tradeoffs Between Honesty And Self-Interest
title_sort damage to dorsolateral prefrontal cortex affects tradeoffs between honesty and self-interest
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177007/
https://www.ncbi.nlm.nih.gov/pubmed/25174003
http://dx.doi.org/10.1038/nn.3798
work_keys_str_mv AT zhulusha damagetodorsolateralprefrontalcortexaffectstradeoffsbetweenhonestyandselfinterest
AT jenkinsadriannac damagetodorsolateralprefrontalcortexaffectstradeoffsbetweenhonestyandselfinterest
AT seteric damagetodorsolateralprefrontalcortexaffectstradeoffsbetweenhonestyandselfinterest
AT scabinidonatella damagetodorsolateralprefrontalcortexaffectstradeoffsbetweenhonestyandselfinterest
AT knightrobertt damagetodorsolateralprefrontalcortexaffectstradeoffsbetweenhonestyandselfinterest
AT chiupearlh damagetodorsolateralprefrontalcortexaffectstradeoffsbetweenhonestyandselfinterest
AT kingcasasbrooks damagetodorsolateralprefrontalcortexaffectstradeoffsbetweenhonestyandselfinterest
AT hsuming damagetodorsolateralprefrontalcortexaffectstradeoffsbetweenhonestyandselfinterest

Ejemplares similares