Ecotin-Like ISP of L. major Promastigotes Fine-Tunes Macrophage Phagocytosis by Limiting the Pericellular Release of Bradykinin from Surface-Bound Kininogens: A Survival Strategy Based on the Silencing of Proinflammatory G-Protein Coupled Kinin B(2) and B(1) Receptors

Inhibitors of serine peptidases (ISPs) expressed by Leishmania major enhance intracellular parasitism in macrophages by targeting neutrophil elastase (NE), a serine protease that couples phagocytosis to the prooxidative TLR(4)/PKR pathway. Here we investigated the functional interplay between ISP-ex...

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Detalles Bibliográficos
Autores principales: Svensjö, Erik, Nogueira de Almeida, Larissa, Vellasco, Lucas, Juliano, Luiz, Scharfstein, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177093/
https://www.ncbi.nlm.nih.gov/pubmed/25294952
http://dx.doi.org/10.1155/2014/143450

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