Cargando…
Carbon Ion Therapy for Early-Stage Non-Small-Cell Lung Cancer
Carbon ion therapy is a type of radiotherapies that can deliver high-dose radiation to a tumor while minimizing the dose delivered to the organs at risk; this profile differs from that of photon radiotherapy. Moreover, carbon ions are classified as high-linear energy transfer radiation and are expec...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177095/ https://www.ncbi.nlm.nih.gov/pubmed/25295269 http://dx.doi.org/10.1155/2014/727962 |
_version_ | 1782336718405369856 |
---|---|
author | Demizu, Yusuke Fujii, Osamu Iwata, Hiromitsu Fuwa, Nobukazu |
author_facet | Demizu, Yusuke Fujii, Osamu Iwata, Hiromitsu Fuwa, Nobukazu |
author_sort | Demizu, Yusuke |
collection | PubMed |
description | Carbon ion therapy is a type of radiotherapies that can deliver high-dose radiation to a tumor while minimizing the dose delivered to the organs at risk; this profile differs from that of photon radiotherapy. Moreover, carbon ions are classified as high-linear energy transfer radiation and are expected to be effective for even photon-resistant tumors. Recently, high-precision radiotherapy modalities such as stereotactic body radiotherapy (SBRT), proton therapy, and carbon ion therapy have been used for patients with early-stage non-small-cell lung cancer, and the results are promising, as, for carbon ion therapy, local control and overall survival rates at 5 years are 80–90% and 40–50%, respectively. Carbon ion therapy may be theoretically superior to SBRT and proton therapy, but the literature that is currently available does not show a statistically significant difference among these treatments. Carbon ion therapy demonstrates a better dose distribution than both SBRT and proton therapy in most cases of early-stage lung cancer. Therefore, carbon ion therapy may be safer for treating patients with adverse conditions such as large tumors, central tumors, and poor pulmonary function. Furthermore, carbon ion therapy may also be suitable for dose escalation and hypofractionation. |
format | Online Article Text |
id | pubmed-4177095 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41770952014-10-07 Carbon Ion Therapy for Early-Stage Non-Small-Cell Lung Cancer Demizu, Yusuke Fujii, Osamu Iwata, Hiromitsu Fuwa, Nobukazu Biomed Res Int Review Article Carbon ion therapy is a type of radiotherapies that can deliver high-dose radiation to a tumor while minimizing the dose delivered to the organs at risk; this profile differs from that of photon radiotherapy. Moreover, carbon ions are classified as high-linear energy transfer radiation and are expected to be effective for even photon-resistant tumors. Recently, high-precision radiotherapy modalities such as stereotactic body radiotherapy (SBRT), proton therapy, and carbon ion therapy have been used for patients with early-stage non-small-cell lung cancer, and the results are promising, as, for carbon ion therapy, local control and overall survival rates at 5 years are 80–90% and 40–50%, respectively. Carbon ion therapy may be theoretically superior to SBRT and proton therapy, but the literature that is currently available does not show a statistically significant difference among these treatments. Carbon ion therapy demonstrates a better dose distribution than both SBRT and proton therapy in most cases of early-stage lung cancer. Therefore, carbon ion therapy may be safer for treating patients with adverse conditions such as large tumors, central tumors, and poor pulmonary function. Furthermore, carbon ion therapy may also be suitable for dose escalation and hypofractionation. Hindawi Publishing Corporation 2014 2014-09-11 /pmc/articles/PMC4177095/ /pubmed/25295269 http://dx.doi.org/10.1155/2014/727962 Text en Copyright © 2014 Yusuke Demizu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Demizu, Yusuke Fujii, Osamu Iwata, Hiromitsu Fuwa, Nobukazu Carbon Ion Therapy for Early-Stage Non-Small-Cell Lung Cancer |
title | Carbon Ion Therapy for Early-Stage Non-Small-Cell Lung Cancer |
title_full | Carbon Ion Therapy for Early-Stage Non-Small-Cell Lung Cancer |
title_fullStr | Carbon Ion Therapy for Early-Stage Non-Small-Cell Lung Cancer |
title_full_unstemmed | Carbon Ion Therapy for Early-Stage Non-Small-Cell Lung Cancer |
title_short | Carbon Ion Therapy for Early-Stage Non-Small-Cell Lung Cancer |
title_sort | carbon ion therapy for early-stage non-small-cell lung cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177095/ https://www.ncbi.nlm.nih.gov/pubmed/25295269 http://dx.doi.org/10.1155/2014/727962 |
work_keys_str_mv | AT demizuyusuke carboniontherapyforearlystagenonsmallcelllungcancer AT fujiiosamu carboniontherapyforearlystagenonsmallcelllungcancer AT iwatahiromitsu carboniontherapyforearlystagenonsmallcelllungcancer AT fuwanobukazu carboniontherapyforearlystagenonsmallcelllungcancer |