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NMR Characterization of an Oligonucleotide Model of the MiR-21 Pre-Element

We have used NMR spectroscopy to characterize an oligonucleotide stem loop structure based on the pre-element of an oncogenic microRNA, miR-21. This predicted stem-loop structure is cleaved from the precursor of miR-21 (pre-miR-21) by the nuclease Dicer. It is also a critical feature recognized by t...

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Detalles Bibliográficos
Autores principales:	Chirayil, Sara, Wu, Qiong, Amezcua, Carlos, Luebke, Kevin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177108/ https://www.ncbi.nlm.nih.gov/pubmed/25250627 http://dx.doi.org/10.1371/journal.pone.0108231

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