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Genome-wide analysis of multiethnic cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma and IOP variability may herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Cons...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177225/ https://www.ncbi.nlm.nih.gov/pubmed/25173106 http://dx.doi.org/10.1038/ng.3087 |
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| author | Hysi, Pirro G Cheng, Ching-Yu Springelkamp, Henriët Macgregor, Stuart Bailey, Jessica N Cooke Wojciechowski, Robert Vitart, Veronique Nag, Abhishek Hewitt, Alex W Höhn, René Venturini, Cristina Mirshahi, Alireza Ramdas, Wishal D. Thorleifsson, Gudmar Vithana, Eranga Khor, Chiea-Chuen Stefansson, Arni B Liao, Jiemin Haines, Jonathan L Amin, Najaf Wang, Ya Xing Wild, Philipp S Ozel, Ayse B Li, Jun Z Fleck, Brian W Zeller, Tanja Staffieri, Sandra E Teo, Yik-Ying Cuellar-Partida, Gabriel Luo, Xiaoyan Allingham, R Rand Richards, Julia E Senft, Andrea Karssen, Lennart C Zheng, Yingfeng Bellenguez, Céline Xu, Liang Iglesias, Adriana I Wilson, James F Kang, Jae H van Leeuwen, Elisabeth M Jonsson, Vesteinn Thorsteinsdottir, Unnur Despriet, Dominiek D.G. Ennis, Sarah Moroi, Sayoko E Martin, Nicholas G Jansonius, Nomdo M Yazar, Seyhan Tai, E-Shyong Amouyel, Philippe Kirwan, James van Koolwijk, Leonieke M.E. Hauser, Michael A Jonasson, Fridbert Leo, Paul Loomis, Stephanie J Fogarty, Rhys Rivadeneira, Fernando Kearns, Lisa Lackner, Karl J de Jong, Paulus T.V.M. Simpson, Claire L Pennell, Craig E Oostra, Ben A Uitterlinden, André G Saw, Seang-Mei Lotery, Andrew J Bailey-Wilson, Joan E Hofman, Albert Vingerling, Johannes R Maubaret, Cécilia Pfeiffer, Norbert Wolfs, Roger C.W. Lemij, Hans G Young, Terri L Pasquale, Louis R Delcourt, Cécile Spector, Timothy D Klaver, Caroline C.W. Small, Kerrin S Burdon, Kathryn P Stefansson, Kari Wong, Tien-Yin Viswanathan, Ananth Mackey, David A Craig, Jamie E Wiggs, Janey L van Duijn, Cornelia M Hammond, Christopher J Aung, Tin |
| author_facet | Hysi, Pirro G Cheng, Ching-Yu Springelkamp, Henriët Macgregor, Stuart Bailey, Jessica N Cooke Wojciechowski, Robert Vitart, Veronique Nag, Abhishek Hewitt, Alex W Höhn, René Venturini, Cristina Mirshahi, Alireza Ramdas, Wishal D. Thorleifsson, Gudmar Vithana, Eranga Khor, Chiea-Chuen Stefansson, Arni B Liao, Jiemin Haines, Jonathan L Amin, Najaf Wang, Ya Xing Wild, Philipp S Ozel, Ayse B Li, Jun Z Fleck, Brian W Zeller, Tanja Staffieri, Sandra E Teo, Yik-Ying Cuellar-Partida, Gabriel Luo, Xiaoyan Allingham, R Rand Richards, Julia E Senft, Andrea Karssen, Lennart C Zheng, Yingfeng Bellenguez, Céline Xu, Liang Iglesias, Adriana I Wilson, James F Kang, Jae H van Leeuwen, Elisabeth M Jonsson, Vesteinn Thorsteinsdottir, Unnur Despriet, Dominiek D.G. Ennis, Sarah Moroi, Sayoko E Martin, Nicholas G Jansonius, Nomdo M Yazar, Seyhan Tai, E-Shyong Amouyel, Philippe Kirwan, James van Koolwijk, Leonieke M.E. Hauser, Michael A Jonasson, Fridbert Leo, Paul Loomis, Stephanie J Fogarty, Rhys Rivadeneira, Fernando Kearns, Lisa Lackner, Karl J de Jong, Paulus T.V.M. Simpson, Claire L Pennell, Craig E Oostra, Ben A Uitterlinden, André G Saw, Seang-Mei Lotery, Andrew J Bailey-Wilson, Joan E Hofman, Albert Vingerling, Johannes R Maubaret, Cécilia Pfeiffer, Norbert Wolfs, Roger C.W. Lemij, Hans G Young, Terri L Pasquale, Louis R Delcourt, Cécile Spector, Timothy D Klaver, Caroline C.W. Small, Kerrin S Burdon, Kathryn P Stefansson, Kari Wong, Tien-Yin Viswanathan, Ananth Mackey, David A Craig, Jamie E Wiggs, Janey L van Duijn, Cornelia M Hammond, Christopher J Aung, Tin |
| author_sort | Hysi, Pirro G |
| collection | PubMed |
| description | Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma and IOP variability may herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multiethnic participants for IOP. We confirm genetic association of known loci for IOP and primary open angle glaucoma (POAG) and identify four new IOP loci located on chromosome 3q25.31 within the FNDC3B gene (p=4.19×10(−08) for rs6445055), two on chromosome 9 (p=2.80×10(−11) for rs2472493 near ABCA1 and p=6.39×10(−11) for rs8176693 within ABO) and one on chromosome 11p11.2 (best p=1.04×10(−11) for rs747782). Separate meta-analyses of four independent POAG cohorts, totaling 4,284 cases and 95,560 controls, show that three of these IOP loci are also associated with POAG. |
| format | Online Article Text |
| id | pubmed-4177225 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-41772252015-04-01 Genome-wide analysis of multiethnic cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma Hysi, Pirro G Cheng, Ching-Yu Springelkamp, Henriët Macgregor, Stuart Bailey, Jessica N Cooke Wojciechowski, Robert Vitart, Veronique Nag, Abhishek Hewitt, Alex W Höhn, René Venturini, Cristina Mirshahi, Alireza Ramdas, Wishal D. Thorleifsson, Gudmar Vithana, Eranga Khor, Chiea-Chuen Stefansson, Arni B Liao, Jiemin Haines, Jonathan L Amin, Najaf Wang, Ya Xing Wild, Philipp S Ozel, Ayse B Li, Jun Z Fleck, Brian W Zeller, Tanja Staffieri, Sandra E Teo, Yik-Ying Cuellar-Partida, Gabriel Luo, Xiaoyan Allingham, R Rand Richards, Julia E Senft, Andrea Karssen, Lennart C Zheng, Yingfeng Bellenguez, Céline Xu, Liang Iglesias, Adriana I Wilson, James F Kang, Jae H van Leeuwen, Elisabeth M Jonsson, Vesteinn Thorsteinsdottir, Unnur Despriet, Dominiek D.G. Ennis, Sarah Moroi, Sayoko E Martin, Nicholas G Jansonius, Nomdo M Yazar, Seyhan Tai, E-Shyong Amouyel, Philippe Kirwan, James van Koolwijk, Leonieke M.E. Hauser, Michael A Jonasson, Fridbert Leo, Paul Loomis, Stephanie J Fogarty, Rhys Rivadeneira, Fernando Kearns, Lisa Lackner, Karl J de Jong, Paulus T.V.M. Simpson, Claire L Pennell, Craig E Oostra, Ben A Uitterlinden, André G Saw, Seang-Mei Lotery, Andrew J Bailey-Wilson, Joan E Hofman, Albert Vingerling, Johannes R Maubaret, Cécilia Pfeiffer, Norbert Wolfs, Roger C.W. Lemij, Hans G Young, Terri L Pasquale, Louis R Delcourt, Cécile Spector, Timothy D Klaver, Caroline C.W. Small, Kerrin S Burdon, Kathryn P Stefansson, Kari Wong, Tien-Yin Viswanathan, Ananth Mackey, David A Craig, Jamie E Wiggs, Janey L van Duijn, Cornelia M Hammond, Christopher J Aung, Tin Nat Genet Article Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma and IOP variability may herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multiethnic participants for IOP. We confirm genetic association of known loci for IOP and primary open angle glaucoma (POAG) and identify four new IOP loci located on chromosome 3q25.31 within the FNDC3B gene (p=4.19×10(−08) for rs6445055), two on chromosome 9 (p=2.80×10(−11) for rs2472493 near ABCA1 and p=6.39×10(−11) for rs8176693 within ABO) and one on chromosome 11p11.2 (best p=1.04×10(−11) for rs747782). Separate meta-analyses of four independent POAG cohorts, totaling 4,284 cases and 95,560 controls, show that three of these IOP loci are also associated with POAG. 2014-08-31 2014-10 /pmc/articles/PMC4177225/ /pubmed/25173106 http://dx.doi.org/10.1038/ng.3087 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Hysi, Pirro G Cheng, Ching-Yu Springelkamp, Henriët Macgregor, Stuart Bailey, Jessica N Cooke Wojciechowski, Robert Vitart, Veronique Nag, Abhishek Hewitt, Alex W Höhn, René Venturini, Cristina Mirshahi, Alireza Ramdas, Wishal D. Thorleifsson, Gudmar Vithana, Eranga Khor, Chiea-Chuen Stefansson, Arni B Liao, Jiemin Haines, Jonathan L Amin, Najaf Wang, Ya Xing Wild, Philipp S Ozel, Ayse B Li, Jun Z Fleck, Brian W Zeller, Tanja Staffieri, Sandra E Teo, Yik-Ying Cuellar-Partida, Gabriel Luo, Xiaoyan Allingham, R Rand Richards, Julia E Senft, Andrea Karssen, Lennart C Zheng, Yingfeng Bellenguez, Céline Xu, Liang Iglesias, Adriana I Wilson, James F Kang, Jae H van Leeuwen, Elisabeth M Jonsson, Vesteinn Thorsteinsdottir, Unnur Despriet, Dominiek D.G. Ennis, Sarah Moroi, Sayoko E Martin, Nicholas G Jansonius, Nomdo M Yazar, Seyhan Tai, E-Shyong Amouyel, Philippe Kirwan, James van Koolwijk, Leonieke M.E. Hauser, Michael A Jonasson, Fridbert Leo, Paul Loomis, Stephanie J Fogarty, Rhys Rivadeneira, Fernando Kearns, Lisa Lackner, Karl J de Jong, Paulus T.V.M. Simpson, Claire L Pennell, Craig E Oostra, Ben A Uitterlinden, André G Saw, Seang-Mei Lotery, Andrew J Bailey-Wilson, Joan E Hofman, Albert Vingerling, Johannes R Maubaret, Cécilia Pfeiffer, Norbert Wolfs, Roger C.W. Lemij, Hans G Young, Terri L Pasquale, Louis R Delcourt, Cécile Spector, Timothy D Klaver, Caroline C.W. Small, Kerrin S Burdon, Kathryn P Stefansson, Kari Wong, Tien-Yin Viswanathan, Ananth Mackey, David A Craig, Jamie E Wiggs, Janey L van Duijn, Cornelia M Hammond, Christopher J Aung, Tin Genome-wide analysis of multiethnic cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma |
| title | Genome-wide analysis of multiethnic cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma |
| title_full | Genome-wide analysis of multiethnic cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma |
| title_fullStr | Genome-wide analysis of multiethnic cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma |
| title_full_unstemmed | Genome-wide analysis of multiethnic cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma |
| title_short | Genome-wide analysis of multiethnic cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma |
| title_sort | genome-wide analysis of multiethnic cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177225/ https://www.ncbi.nlm.nih.gov/pubmed/25173106 http://dx.doi.org/10.1038/ng.3087 |
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