The functional role of long non-coding RNAs and epigenetics

Long non-coding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. The post-transcriptional regulation is influenced by these lncRNAs by interfering with the microRNA pathways, involving in diverse cellular processes. The regulation of gene expression by lncRNAs at the ep...

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Detalles Bibliográficos
Autor principal: Cao, Jinneng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177375/
https://www.ncbi.nlm.nih.gov/pubmed/25276098
http://dx.doi.org/10.1186/1480-9222-16-11
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author Cao, Jinneng
author_facet Cao, Jinneng
author_sort Cao, Jinneng
collection PubMed
description Long non-coding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. The post-transcriptional regulation is influenced by these lncRNAs by interfering with the microRNA pathways, involving in diverse cellular processes. The regulation of gene expression by lncRNAs at the epigenetic level, transcriptional and post-transcriptional level have been well known and widely studied. Recent recognition that lncRNAs make effects in many biological and pathological processes such as stem cell pluripotency, neurogenesis, oncogenesis and etc. This review will focus on the functional roles of lncRNAs in epigenetics and related research progress will be summarized.
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spelling pubmed-41773752014-09-29 The functional role of long non-coding RNAs and epigenetics Cao, Jinneng Biol Proced Online Review Long non-coding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. The post-transcriptional regulation is influenced by these lncRNAs by interfering with the microRNA pathways, involving in diverse cellular processes. The regulation of gene expression by lncRNAs at the epigenetic level, transcriptional and post-transcriptional level have been well known and widely studied. Recent recognition that lncRNAs make effects in many biological and pathological processes such as stem cell pluripotency, neurogenesis, oncogenesis and etc. This review will focus on the functional roles of lncRNAs in epigenetics and related research progress will be summarized. BioMed Central 2014-09-15 /pmc/articles/PMC4177375/ /pubmed/25276098 http://dx.doi.org/10.1186/1480-9222-16-11 Text en Copyright © 2014 Cao; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Cao, Jinneng
The functional role of long non-coding RNAs and epigenetics
title The functional role of long non-coding RNAs and epigenetics
title_full The functional role of long non-coding RNAs and epigenetics
title_fullStr The functional role of long non-coding RNAs and epigenetics
title_full_unstemmed The functional role of long non-coding RNAs and epigenetics
title_short The functional role of long non-coding RNAs and epigenetics
title_sort functional role of long non-coding rnas and epigenetics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177375/
https://www.ncbi.nlm.nih.gov/pubmed/25276098
http://dx.doi.org/10.1186/1480-9222-16-11
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