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Contourlet Textual Features: Improving the Diagnosis of Solitary Pulmonary Nodules in Two Dimensional CT Images
OBJECTIVE: To determine the value of contourlet textural features obtained from solitary pulmonary nodules in two dimensional CT images used in diagnoses of lung cancer. MATERIALS AND METHODS: A total of 6,299 CT images were acquired from 336 patients, with 1,454 benign pulmonary nodule images from...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177406/ https://www.ncbi.nlm.nih.gov/pubmed/25250576 http://dx.doi.org/10.1371/journal.pone.0108465 |
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author | Wang, Jingjing Sun, Tao Gao, Ni Menon, Desmond Dev Luo, Yanxia Gao, Qi Li, Xia Wang, Wei Zhu, Huiping Lv, Pingxin Liang, Zhigang Tao, Lixin Liu, Xiangtong Guo, Xiuhua |
author_facet | Wang, Jingjing Sun, Tao Gao, Ni Menon, Desmond Dev Luo, Yanxia Gao, Qi Li, Xia Wang, Wei Zhu, Huiping Lv, Pingxin Liang, Zhigang Tao, Lixin Liu, Xiangtong Guo, Xiuhua |
author_sort | Wang, Jingjing |
collection | PubMed |
description | OBJECTIVE: To determine the value of contourlet textural features obtained from solitary pulmonary nodules in two dimensional CT images used in diagnoses of lung cancer. MATERIALS AND METHODS: A total of 6,299 CT images were acquired from 336 patients, with 1,454 benign pulmonary nodule images from 84 patients (50 male, 34 female) and 4,845 malignant from 252 patients (150 male, 102 female). Further to this, nineteen patient information categories, which included seven demographic parameters and twelve morphological features, were also collected. A contourlet was used to extract fourteen types of textural features. These were then used to establish three support vector machine models. One comprised a database constructed of nineteen collected patient information categories, another included contourlet textural features and the third one contained both sets of information. Ten-fold cross-validation was used to evaluate the diagnosis results for the three databases, with sensitivity, specificity, accuracy, the area under the curve (AUC), precision, Youden index, and F-measure were used as the assessment criteria. In addition, the synthetic minority over-sampling technique (SMOTE) was used to preprocess the unbalanced data. RESULTS: Using a database containing textural features and patient information, sensitivity, specificity, accuracy, AUC, precision, Youden index, and F-measure were: 0.95, 0.71, 0.89, 0.89, 0.92, 0.66, and 0.93 respectively. These results were higher than results derived using the database without textural features (0.82, 0.47, 0.74, 0.67, 0.84, 0.29, and 0.83 respectively) as well as the database comprising only textural features (0.81, 0.64, 0.67, 0.72, 0.88, 0.44, and 0.85 respectively). Using the SMOTE as a pre-processing procedure, new balanced database generated, including observations of 5,816 benign ROIs and 5,815 malignant ROIs, and accuracy was 0.93. CONCLUSION: Our results indicate that the combined contourlet textural features of solitary pulmonary nodules in CT images with patient profile information could potentially improve the diagnosis of lung cancer. |
format | Online Article Text |
id | pubmed-4177406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-41774062014-10-02 Contourlet Textual Features: Improving the Diagnosis of Solitary Pulmonary Nodules in Two Dimensional CT Images Wang, Jingjing Sun, Tao Gao, Ni Menon, Desmond Dev Luo, Yanxia Gao, Qi Li, Xia Wang, Wei Zhu, Huiping Lv, Pingxin Liang, Zhigang Tao, Lixin Liu, Xiangtong Guo, Xiuhua PLoS One Research Article OBJECTIVE: To determine the value of contourlet textural features obtained from solitary pulmonary nodules in two dimensional CT images used in diagnoses of lung cancer. MATERIALS AND METHODS: A total of 6,299 CT images were acquired from 336 patients, with 1,454 benign pulmonary nodule images from 84 patients (50 male, 34 female) and 4,845 malignant from 252 patients (150 male, 102 female). Further to this, nineteen patient information categories, which included seven demographic parameters and twelve morphological features, were also collected. A contourlet was used to extract fourteen types of textural features. These were then used to establish three support vector machine models. One comprised a database constructed of nineteen collected patient information categories, another included contourlet textural features and the third one contained both sets of information. Ten-fold cross-validation was used to evaluate the diagnosis results for the three databases, with sensitivity, specificity, accuracy, the area under the curve (AUC), precision, Youden index, and F-measure were used as the assessment criteria. In addition, the synthetic minority over-sampling technique (SMOTE) was used to preprocess the unbalanced data. RESULTS: Using a database containing textural features and patient information, sensitivity, specificity, accuracy, AUC, precision, Youden index, and F-measure were: 0.95, 0.71, 0.89, 0.89, 0.92, 0.66, and 0.93 respectively. These results were higher than results derived using the database without textural features (0.82, 0.47, 0.74, 0.67, 0.84, 0.29, and 0.83 respectively) as well as the database comprising only textural features (0.81, 0.64, 0.67, 0.72, 0.88, 0.44, and 0.85 respectively). Using the SMOTE as a pre-processing procedure, new balanced database generated, including observations of 5,816 benign ROIs and 5,815 malignant ROIs, and accuracy was 0.93. CONCLUSION: Our results indicate that the combined contourlet textural features of solitary pulmonary nodules in CT images with patient profile information could potentially improve the diagnosis of lung cancer. Public Library of Science 2014-09-24 /pmc/articles/PMC4177406/ /pubmed/25250576 http://dx.doi.org/10.1371/journal.pone.0108465 Text en © 2014 Wang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Wang, Jingjing Sun, Tao Gao, Ni Menon, Desmond Dev Luo, Yanxia Gao, Qi Li, Xia Wang, Wei Zhu, Huiping Lv, Pingxin Liang, Zhigang Tao, Lixin Liu, Xiangtong Guo, Xiuhua Contourlet Textual Features: Improving the Diagnosis of Solitary Pulmonary Nodules in Two Dimensional CT Images |
title | Contourlet Textual Features: Improving the Diagnosis of Solitary Pulmonary Nodules in Two Dimensional CT Images |
title_full | Contourlet Textual Features: Improving the Diagnosis of Solitary Pulmonary Nodules in Two Dimensional CT Images |
title_fullStr | Contourlet Textual Features: Improving the Diagnosis of Solitary Pulmonary Nodules in Two Dimensional CT Images |
title_full_unstemmed | Contourlet Textual Features: Improving the Diagnosis of Solitary Pulmonary Nodules in Two Dimensional CT Images |
title_short | Contourlet Textual Features: Improving the Diagnosis of Solitary Pulmonary Nodules in Two Dimensional CT Images |
title_sort | contourlet textual features: improving the diagnosis of solitary pulmonary nodules in two dimensional ct images |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177406/ https://www.ncbi.nlm.nih.gov/pubmed/25250576 http://dx.doi.org/10.1371/journal.pone.0108465 |
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