Rb1 loss modifies but does not initiate alveolar rhabdomyosarcoma

BACKGROUND: Alveolar rhabdomyosarcoma (aRMS) is a myogenic childhood sarcoma frequently associated with a translocation-mediated fusion gene, Pax3:Foxo1a. METHODS: We investigated the complementary role of Rb1 loss in aRMS tumor initiation and progression using conditional mouse models. RESULTS: Rb1...

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Detalles Bibliográficos
Autores principales: Kikuchi, Ken, Taniguchi, Eri, Chen, Hung-I Harry, Svalina, Matthew N, Abraham, Jinu, Huang, Elaine T, Nishijo, Koichi, Davis, Sean, Louden, Christopher, Zarzabal, Lee Ann, Recht, Olivia, Bajwa, Ayeza, Berlow, Noah, Suelves, Mònica, Perkins, Sherrie L, Meltzer, Paul S, Mansoor, Atiya, Michalek, Joel E, Chen, Yidong, Rubin, Brian P, Keller, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177545/
https://www.ncbi.nlm.nih.gov/pubmed/24274149
http://dx.doi.org/10.1186/2044-5040-3-27

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