Prognostic value and functional consequences of cell cycle inhibitor p27(Kip1) loss in medulloblastoma

BACKGROUND: The cyclin-dependent kinase inhibitor p27(Kip1) functions during normal cerebellar development and has demonstrated tumor suppressor functions in mouse models of medulloblastoma. Because P27 loss is associated with increased proliferation, we assessed whether P27 absence in surgical medu...

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Detalles Bibliográficos
Autores principales: Hatton, Beryl A, Ellison, David W, Gajjar, Amar, Kool, Marcel, Fero, Matthew, Olson, James M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177552/
https://www.ncbi.nlm.nih.gov/pubmed/24252239
http://dx.doi.org/10.1186/2050-7771-1-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177552/
https://www.ncbi.nlm.nih.gov/pubmed/24252239
http://dx.doi.org/10.1186/2050-7771-1-14

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