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α(1)-antitrypsin modulates microglial-mediated neuroinflammation and protects microglial cells from amyloid-β-induced toxicity

BACKGROUND: One hallmark of Alzheimer disease is microglial activation. Therapeutic approaches for this neurodegenerative disease include the modulation of microglial cells. α(1)-antitrypsin (A1AT) has been shown to exert anti-inflammatory effects on macrophages and lung epithelial cells and an inhi...

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Detalles Bibliográficos
Autores principales:	Gold, Maike, Dolga, Amalia M, Koepke, Janine, Mengel, David, Culmsee, Carsten, Dodel, Richard, Koczulla, Andreas Rembert, Bach, Jan-Philipp
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177587/ https://www.ncbi.nlm.nih.gov/pubmed/25245568 http://dx.doi.org/10.1186/s12974-014-0165-8

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