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Clique of Functional Hubs Orchestrates Population Bursts in Developmentally Regulated Neural Networks

It has recently been discovered that single neuron stimulation can impact network dynamics in immature and adult neuronal circuits. Here we report a novel mechanism which can explain in neuronal circuits, at an early stage of development, the peculiar role played by a few specific neurons in promoti...

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Autores principales: Luccioli, Stefano, Ben-Jacob, Eshel, Barzilai, Ari, Bonifazi, Paolo, Torcini, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177675/
https://www.ncbi.nlm.nih.gov/pubmed/25255443
http://dx.doi.org/10.1371/journal.pcbi.1003823
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author Luccioli, Stefano
Ben-Jacob, Eshel
Barzilai, Ari
Bonifazi, Paolo
Torcini, Alessandro
author_facet Luccioli, Stefano
Ben-Jacob, Eshel
Barzilai, Ari
Bonifazi, Paolo
Torcini, Alessandro
author_sort Luccioli, Stefano
collection PubMed
description It has recently been discovered that single neuron stimulation can impact network dynamics in immature and adult neuronal circuits. Here we report a novel mechanism which can explain in neuronal circuits, at an early stage of development, the peculiar role played by a few specific neurons in promoting/arresting the population activity. For this purpose, we consider a standard neuronal network model, with short-term synaptic plasticity, whose population activity is characterized by bursting behavior. The addition of developmentally inspired constraints and correlations in the distribution of the neuronal connectivities and excitabilities leads to the emergence of functional hub neurons, whose stimulation/deletion is critical for the network activity. Functional hubs form a clique, where a precise sequential activation of the neurons is essential to ignite collective events without any need for a specific topological architecture. Unsupervised time-lagged firings of supra-threshold cells, in connection with coordinated entrainments of near-threshold neurons, are the key ingredients to orchestrate population activity.
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spelling pubmed-41776752014-10-02 Clique of Functional Hubs Orchestrates Population Bursts in Developmentally Regulated Neural Networks Luccioli, Stefano Ben-Jacob, Eshel Barzilai, Ari Bonifazi, Paolo Torcini, Alessandro PLoS Comput Biol Research Article It has recently been discovered that single neuron stimulation can impact network dynamics in immature and adult neuronal circuits. Here we report a novel mechanism which can explain in neuronal circuits, at an early stage of development, the peculiar role played by a few specific neurons in promoting/arresting the population activity. For this purpose, we consider a standard neuronal network model, with short-term synaptic plasticity, whose population activity is characterized by bursting behavior. The addition of developmentally inspired constraints and correlations in the distribution of the neuronal connectivities and excitabilities leads to the emergence of functional hub neurons, whose stimulation/deletion is critical for the network activity. Functional hubs form a clique, where a precise sequential activation of the neurons is essential to ignite collective events without any need for a specific topological architecture. Unsupervised time-lagged firings of supra-threshold cells, in connection with coordinated entrainments of near-threshold neurons, are the key ingredients to orchestrate population activity. Public Library of Science 2014-09-25 /pmc/articles/PMC4177675/ /pubmed/25255443 http://dx.doi.org/10.1371/journal.pcbi.1003823 Text en © 2014 Luccioli et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Luccioli, Stefano
Ben-Jacob, Eshel
Barzilai, Ari
Bonifazi, Paolo
Torcini, Alessandro
Clique of Functional Hubs Orchestrates Population Bursts in Developmentally Regulated Neural Networks
title Clique of Functional Hubs Orchestrates Population Bursts in Developmentally Regulated Neural Networks
title_full Clique of Functional Hubs Orchestrates Population Bursts in Developmentally Regulated Neural Networks
title_fullStr Clique of Functional Hubs Orchestrates Population Bursts in Developmentally Regulated Neural Networks
title_full_unstemmed Clique of Functional Hubs Orchestrates Population Bursts in Developmentally Regulated Neural Networks
title_short Clique of Functional Hubs Orchestrates Population Bursts in Developmentally Regulated Neural Networks
title_sort clique of functional hubs orchestrates population bursts in developmentally regulated neural networks
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177675/
https://www.ncbi.nlm.nih.gov/pubmed/25255443
http://dx.doi.org/10.1371/journal.pcbi.1003823
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