Extracellular Matrix Defects in Aneurysmal Fibulin-4 Mice Predispose to Lung Emphysema

BACKGROUND: In this study we set out to investigate the clinically observed relationship between chronic obstructive pulmonary disease (COPD) and aortic aneurysms. We tested the hypothesis that an inherited deficiency of connective tissue might play a role in the combined development of pulmonary em...

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Detalles Bibliográficos
Autores principales: Ramnath, Natasja W. M., van de Luijtgaarden, Koen M., van der Pluijm, Ingrid, van Nimwegen, Menno, van Heijningen, Paula M., Swagemakers, Sigrid M. A., van Thiel, Bibi S., Ridwan, Ruziedi Y., van Vliet, Nicole, Vermeij, Marcel, Hawinkels, Luuk J. A. C., de Munck, Anne, Dzyubachyk, Oleh, Meijering, Erik, van der Spek, Peter, Rottier, Robbert, Yanagisawa, Hiromi, Hendriks, Rudi W., Kanaar, Roland, Rouwet, Ellen V., Kleinjan, Alex, Essers, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177830/
https://www.ncbi.nlm.nih.gov/pubmed/25255451
http://dx.doi.org/10.1371/journal.pone.0106054

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