Ontogeny of Recognition Specificity and Functionality for the Broadly Neutralizing Anti-HIV Antibody 4E10

The process of antibody ontogeny typically improves affinity, on-rate, and thermostability, narrows polyspecificity, and rigidifies the combining site to the conformer optimal for binding from the broader ensemble accessible to the precursor. However, many broadly-neutralizing anti-HIV antibodies in...

Descripción completa

Detalles Bibliográficos
Autores principales: Finton, Kathryn A. K., Friend, Della, Jaffe, James, Gewe, Mesfin, Holmes, Margaret A., Larman, H. Benjamin, Stuart, Andrew, Larimore, Kevin, Greenberg, Philip D., Elledge, Stephen J., Stamatatos, Leonidas, Strong, Roland K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177983/
https://www.ncbi.nlm.nih.gov/pubmed/25254371
http://dx.doi.org/10.1371/journal.ppat.1004403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177983/
https://www.ncbi.nlm.nih.gov/pubmed/25254371
http://dx.doi.org/10.1371/journal.ppat.1004403

Ejemplares similares