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Ontogeny of Recognition Specificity and Functionality for the Broadly Neutralizing Anti-HIV Antibody 4E10
The process of antibody ontogeny typically improves affinity, on-rate, and thermostability, narrows polyspecificity, and rigidifies the combining site to the conformer optimal for binding from the broader ensemble accessible to the precursor. However, many broadly-neutralizing anti-HIV antibodies in...
Autores principales: | Finton, Kathryn A. K., Friend, Della, Jaffe, James, Gewe, Mesfin, Holmes, Margaret A., Larman, H. Benjamin, Stuart, Andrew, Larimore, Kevin, Greenberg, Philip D., Elledge, Stephen J., Stamatatos, Leonidas, Strong, Roland K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177983/ https://www.ncbi.nlm.nih.gov/pubmed/25254371 http://dx.doi.org/10.1371/journal.ppat.1004403 |
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