Cargando…

A MIV-150/Zinc Acetate Gel Inhibits SHIV-RT Infection in Macaque Vaginal Explants

To extend our observations that single or repeated application of a gel containing the NNRTI MIV-150 (M) and zinc acetate dihydrate (ZA) in carrageenan (CG) (MZC) inhibits vaginal transmission of simian/human immunodeficiency virus (SHIV)-RT in macaques, we evaluated safety and anti-SHIV-RT activity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barnable, Patrick, Calenda, Giulia, Ouattara, Louise, Gettie, Agegnehu, Blanchard, James, Jean-Pierre, Ninochka, Kizima, Larisa, Rodríguez, Aixa, Abraham, Ciby, Menon, Radhika, Seidor, Samantha, Cooney, Michael L., Roberts, Kevin D., Sperling, Rhoda, Piatak, Michael, Lifson, Jeffrey D., Fernandez-Romero, Jose A., Zydowsky, Thomas M., Robbiani, Melissa, Teleshova, Natalia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178065/ https://www.ncbi.nlm.nih.gov/pubmed/25259616 http://dx.doi.org/10.1371/journal.pone.0108109

Ejemplares similares

Exposure to MIV-150 from a High-Dose Intravaginal Ring Results in Limited Emergence of Drug Resistance Mutations in SHIV-RT Infected Rhesus Macaques
por: Hsu, Mayla, et al.
Publicado: (2014)

An Antiretroviral/Zinc Combination Gel Provides 24 Hours of Complete Protection against Vaginal SHIV Infection in Macaques
por: Kenney, Jessica, et al.
Publicado: (2011)

A Potent Combination Microbicide that Targets SHIV-RT, HSV-2 and HPV
por: Kizima, Larisa, et al.
Publicado: (2014)

A Novel Microbicide/Contraceptive Intravaginal Ring Protects Macaque Genital Mucosa against SHIV-RT Infection Ex Vivo
por: Villegas, Guillermo, et al.
Publicado: (2016)

Multipurpose Prevention Approaches with Antiretroviral-Based Formulations
por: Jean-Pierre, Ninochka, et al.
Publicado: (2016)

An intravaginal ring that releases three antiviral agents and a contraceptive blocks SHIV-RT infection, reduces HSV-2 shedding, and suppresses hormonal cycling in rhesus macaques
por: Derby, Nina, et al.
Publicado: (2017)

Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo
por: Derby, Nina, et al.
Publicado: (2018)

HSV-2-Driven Increase in the Expression of α(4)β(7) Correlates with Increased Susceptibility to Vaginal SHIV(SF162P3) Infection
por: Goode, Diana, et al.
Publicado: (2014)

First-in-Human Trial of MIV-150 and Zinc Acetate Coformulated in a Carrageenan Gel: Safety, Pharmacokinetics, Acceptability, Adherence, and Pharmacodynamics
por: Friedland, Barbara A., et al.
Publicado: (2016)

HSV-2 Infection of Dendritic Cells Amplifies a Highly Susceptible HIV-1 Cell Target
por: Martinelli, Elena, et al.
Publicado: (2011)

In Vivo Binding and Retention of CD4-Specific DARPin 57.2 in Macaques
por: Pugach, Pavel, et al.
Publicado: (2010)

Efficacy of Carraguard®-Based Microbicides In Vivo Despite Variable In Vitro Activity
por: Turville, Stuart G., et al.
Publicado: (2008)

Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus
por: Levendosky, Keith, et al.
Publicado: (2015)

A Macaque Model to Study Vaginal HSV-2/Immunodeficiency Virus Co-Infection and the Impact of HSV-2 on Microbicide Efficacy
por: Crostarosa, Federica, et al.
Publicado: (2009)

A Tonsillar PolyICLC/AT-2 SIV Therapeutic Vaccine Maintains Low Viremia Following Antiretroviral Therapy Cessation
por: Vagenas, Panagiotis, et al.
Publicado: (2010)

A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α(4)β(7) and Fails to Prevent Mucosal Transmission of SHIV-SF162P3
por: Arrode-Brusés, Géraldine, et al.
Publicado: (2016)

Correction: A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α(4)β(7) and Fails to Prevent Mucosal Transmission of SHIV-SF162P3
por: Arrode-Brusés, Géraldine, et al.
Publicado: (2016)

Experimental Oral Herpes Simplex Virus-1 (HSV-1) Co-infection in Simian Immunodeficiency Virus (SIV)-Infected Rhesus Macaques
por: Aravantinou, Meropi, et al.
Publicado: (2017)

Comparative transcriptome analysis of the human endocervix and ectocervix during the proliferative and secretory phases of the menstrual cycle
por: Mukhopadhyay, S., et al.
Publicado: (2019)

PolyICLC Exerts Pro- and Anti-HIV Effects on the DC-T Cell Milieu In Vitro and In Vivo
por: Aravantinou, Meropi, et al.
Publicado: (2016)

Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques
por: Calenda, Giulia, et al.
Publicado: (2019)

Persistence of Viral Reservoirs in Multiple Tissues after Antiretroviral Therapy Suppression in a Macaque RT-SHIV Model
por: Kline, Christopher, et al.
Publicado: (2013)

Mucosal transmissibility, disease induction and coreceptor switching of R5 SHIV(SF162P3N) molecular clones in rhesus macaques
por: Ren, Wuze, et al.
Publicado: (2013)

Results of a phase 1, randomized, placebo-controlled first-in-human trial of griffithsin formulated in a carrageenan vaginal gel
por: Teleshova, Natalia, et al.
Publicado: (2022)

Estradiol inhibits HIV-1(BaL) infection and induces CFL1 expression in peripheral blood mononuclear cells and endocervical mucosa
por: Verma, N., et al.
Publicado: (2022)

Gammaherpesvirus infection and malignant disease in rhesus macaques experimentally infected with SIV or SHIV
por: Marshall, Vickie A., et al.
Publicado: (2018)

Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711
por: Lindström, Erik, et al.
Publicado: (2018)

Validation and recalibration of OxMIV in predicting violent behaviour in patients with schizophrenia spectrum disorders
por: Lamsma, Jelle, et al.
Publicado: (2022)

The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis
por: Lindström, Erik, et al.
Publicado: (2018)

RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy
por: Shao, Wei, et al.
Publicado: (2009)

Modified-dropless protocol (nil intraocular) for micro-incision vitrectomy surgery (MIVS): a retrospective pilot study
por: Garcia-O’Farrill, Noraliz, et al.
Publicado: (2023)

MiniCD4 Microbicide Prevents HIV Infection of Human Mucosal Explants and Vaginal Transmission of SHIV(162P3) in Cynomolgus Macaques
por: Dereuddre-Bosquet, Nathalie, et al.
Publicado: (2012)

Sex Hormones Selectively Impact the Endocervical Mucosal Microenvironment: Implications for HIV Transmission
por: Goode, Diana, et al.
Publicado: (2014)

Rectal HSV-2 Infection May Increase Rectal SIV Acquisition Even in the Context of SIVΔnef Vaccination
por: Guerra-Pérez, Natalia, et al.
Publicado: (2016)

Research on Defect Detection in Kubo Peach Based on Hyperspectral Imaging Technology Combined with CARS-MIV-GA-SVM Method
por: Zhang, Lixiu, et al.
Publicado: (2023)

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges
por: Gardner, Matthew R., et al.
Publicado: (2015)

Assessing violence risk in first-episode psychosis: external validation, updating and net benefit of a prediction tool (OxMIV)
por: Whiting, Daniel, et al.
Publicado: (2023)

Efecto del MIV acurio contra vecuronio sobre la presión intraocular en pacientes programados para extracción de catarata
por: Soto Cabrera, Ismenia
Publicado: (1997)

Construction of a predictive model based on MIV-SVR for prognosis and length of stay in patients with traumatic brain injury: Retrospective cohort study
por: Pan, Yifeng, et al.
Publicado: (2023)

Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes
por: Watson, Dionysios C., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_r0b0gocvdfgobblci27q20slhs