Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations

BACKGROUND: Endocrine FGF21 and FGF19 target adipocytes and hepatocytes through betaKlotho (KLB) and FGFR tyrosine kinases effecting glucose, lipid and energy metabolism. Both factors alleviate obesity and metabolic abnormalities which are contributing factors to breast tumor progression. Genomic ma...

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Detalles Bibliográficos
Autores principales: Luo, Yongde, Yang, Chaofeng, Ye, Min, Jin, Chengliu, Abbruzzese, James L, Lee, Mong-Hong, Yeung, Sai-Ching J, McKeehan, Wallace L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178208/
https://www.ncbi.nlm.nih.gov/pubmed/24279986
http://dx.doi.org/10.1186/2049-3002-1-21

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