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Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress
BACKGROUND: A variety of oncogenic and environmental factors alter tumor metabolism to serve the distinct cellular biosynthetic and bioenergetic needs present during oncogenesis. Extracellular acidosis is a common microenvironmental stress in solid tumors, but little is known about its metabolic inf...
Autores principales: | LaMonte, Gregory, Tang, Xiaohu, Chen, Julia Ling-Yu, Wu, Jianli, Ding, Chien-Kuang Cornelia, Keenan, Melissa M, Sangokoya, Carolyn, Kung, Hsiu-Ni, Ilkayeva, Olga, Boros, László G, Newgard, Christopher B, Chi, Jen-Tsan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178214/ https://www.ncbi.nlm.nih.gov/pubmed/24359630 http://dx.doi.org/10.1186/2049-3002-1-23 |
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