Cargando…

Arrhythmic Song Exposure Increases ZENK Expression in Auditory Cortical Areas and Nucleus Taeniae of the Adult Zebra Finch

Rhythm is important in the production of motor sequences such as speech and song. Deficits in rhythm processing have been implicated in human disorders that affect speech and language processing, including stuttering, autism, and dyslexia. Songbirds provide a tractable model for studying the neural...

Descripción completa

Detalles Bibliográficos
Autores principales: Lampen, Jennifer, Jones, Katherine, McAuley, J. Devin, Chang, Soo-Eun, Wade, Juli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178233/
https://www.ncbi.nlm.nih.gov/pubmed/25259620
http://dx.doi.org/10.1371/journal.pone.0108841
_version_ 1782336918042705920
author Lampen, Jennifer
Jones, Katherine
McAuley, J. Devin
Chang, Soo-Eun
Wade, Juli
author_facet Lampen, Jennifer
Jones, Katherine
McAuley, J. Devin
Chang, Soo-Eun
Wade, Juli
author_sort Lampen, Jennifer
collection PubMed
description Rhythm is important in the production of motor sequences such as speech and song. Deficits in rhythm processing have been implicated in human disorders that affect speech and language processing, including stuttering, autism, and dyslexia. Songbirds provide a tractable model for studying the neural underpinnings of rhythm processing due to parallels with humans in neural structures and vocal learning patterns. In this study, adult zebra finches were exposed to naturally rhythmic conspecific song or arrhythmic song. Immunohistochemistry for the immediate early gene ZENK was used to detect neural activation in response to these two types of stimuli. ZENK was increased in response to arrhythmic song in the auditory association cortex homologs, caudomedial nidopallium (NCM) and caudomedial mesopallium (CMM), and the avian amygdala, nucleus taeniae (Tn). CMM also had greater ZENK labeling in females than males. The increased neural activity in NCM and CMM during perception of arrhythmic stimuli parallels increased activity in the human auditory cortex following exposure to unexpected, or perturbed, auditory stimuli. These auditory areas may be detecting errors in arrhythmic song when comparing it to a stored template of how conspecific song is expected to sound. CMM may also be important for females in evaluating songs of potential mates. In the context of other research in songbirds, we suggest that the increased activity in Tn may be related to the value of song for assessing mate choice and bonding or it may be related to perception of arrhythmic song as aversive.
format Online
Article
Text
id pubmed-4178233
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-41782332014-10-02 Arrhythmic Song Exposure Increases ZENK Expression in Auditory Cortical Areas and Nucleus Taeniae of the Adult Zebra Finch Lampen, Jennifer Jones, Katherine McAuley, J. Devin Chang, Soo-Eun Wade, Juli PLoS One Research Article Rhythm is important in the production of motor sequences such as speech and song. Deficits in rhythm processing have been implicated in human disorders that affect speech and language processing, including stuttering, autism, and dyslexia. Songbirds provide a tractable model for studying the neural underpinnings of rhythm processing due to parallels with humans in neural structures and vocal learning patterns. In this study, adult zebra finches were exposed to naturally rhythmic conspecific song or arrhythmic song. Immunohistochemistry for the immediate early gene ZENK was used to detect neural activation in response to these two types of stimuli. ZENK was increased in response to arrhythmic song in the auditory association cortex homologs, caudomedial nidopallium (NCM) and caudomedial mesopallium (CMM), and the avian amygdala, nucleus taeniae (Tn). CMM also had greater ZENK labeling in females than males. The increased neural activity in NCM and CMM during perception of arrhythmic stimuli parallels increased activity in the human auditory cortex following exposure to unexpected, or perturbed, auditory stimuli. These auditory areas may be detecting errors in arrhythmic song when comparing it to a stored template of how conspecific song is expected to sound. CMM may also be important for females in evaluating songs of potential mates. In the context of other research in songbirds, we suggest that the increased activity in Tn may be related to the value of song for assessing mate choice and bonding or it may be related to perception of arrhythmic song as aversive. Public Library of Science 2014-09-26 /pmc/articles/PMC4178233/ /pubmed/25259620 http://dx.doi.org/10.1371/journal.pone.0108841 Text en © 2014 Lampen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lampen, Jennifer
Jones, Katherine
McAuley, J. Devin
Chang, Soo-Eun
Wade, Juli
Arrhythmic Song Exposure Increases ZENK Expression in Auditory Cortical Areas and Nucleus Taeniae of the Adult Zebra Finch
title Arrhythmic Song Exposure Increases ZENK Expression in Auditory Cortical Areas and Nucleus Taeniae of the Adult Zebra Finch
title_full Arrhythmic Song Exposure Increases ZENK Expression in Auditory Cortical Areas and Nucleus Taeniae of the Adult Zebra Finch
title_fullStr Arrhythmic Song Exposure Increases ZENK Expression in Auditory Cortical Areas and Nucleus Taeniae of the Adult Zebra Finch
title_full_unstemmed Arrhythmic Song Exposure Increases ZENK Expression in Auditory Cortical Areas and Nucleus Taeniae of the Adult Zebra Finch
title_short Arrhythmic Song Exposure Increases ZENK Expression in Auditory Cortical Areas and Nucleus Taeniae of the Adult Zebra Finch
title_sort arrhythmic song exposure increases zenk expression in auditory cortical areas and nucleus taeniae of the adult zebra finch
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178233/
https://www.ncbi.nlm.nih.gov/pubmed/25259620
http://dx.doi.org/10.1371/journal.pone.0108841
work_keys_str_mv AT lampenjennifer arrhythmicsongexposureincreaseszenkexpressioninauditorycorticalareasandnucleustaeniaeoftheadultzebrafinch
AT joneskatherine arrhythmicsongexposureincreaseszenkexpressioninauditorycorticalareasandnucleustaeniaeoftheadultzebrafinch
AT mcauleyjdevin arrhythmicsongexposureincreaseszenkexpressioninauditorycorticalareasandnucleustaeniaeoftheadultzebrafinch
AT changsooeun arrhythmicsongexposureincreaseszenkexpressioninauditorycorticalareasandnucleustaeniaeoftheadultzebrafinch
AT wadejuli arrhythmicsongexposureincreaseszenkexpressioninauditorycorticalareasandnucleustaeniaeoftheadultzebrafinch