Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS: a case report

OBJECTIVE: We report the clinical application of intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging to diagnose a case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) in the acute phase. RESULTS: On IVIM MR Images of this patient, higher...

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Autores principales: Uehara, Ryuji, Yamashita, Koji, Hiwatashi, Akio, Togao, Osamu, Kikuchi, Kazufumi, Yokoyama, Jun, Matsuse, Dai, Yoshiura, Takashi, Honda, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178247/
https://www.ncbi.nlm.nih.gov/pubmed/25365795
http://dx.doi.org/10.1002/brb3.282
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author Uehara, Ryuji
Yamashita, Koji
Hiwatashi, Akio
Togao, Osamu
Kikuchi, Kazufumi
Yokoyama, Jun
Matsuse, Dai
Yoshiura, Takashi
Honda, Hiroshi
author_facet Uehara, Ryuji
Yamashita, Koji
Hiwatashi, Akio
Togao, Osamu
Kikuchi, Kazufumi
Yokoyama, Jun
Matsuse, Dai
Yoshiura, Takashi
Honda, Hiroshi
author_sort Uehara, Ryuji
collection PubMed
description OBJECTIVE: We report the clinical application of intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging to diagnose a case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) in the acute phase. RESULTS: On IVIM MR Images of this patient, higher perfusion (f) and diffusion (D) values in the left occipital and temporal lobes were found compared to the contralateral areas. CONCLUSION: These findings imply a breakdown of autoregulation with hyperperfusion and vasogenic edema during the acute phase of MELAS, as described in previous reports. IVIM imaging is a valuable, noninvasive tool that simultaneously quantifies perfusion and diffusion parameters.
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spelling pubmed-41782472014-10-08 Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS: a case report Uehara, Ryuji Yamashita, Koji Hiwatashi, Akio Togao, Osamu Kikuchi, Kazufumi Yokoyama, Jun Matsuse, Dai Yoshiura, Takashi Honda, Hiroshi Brain Behav Methods OBJECTIVE: We report the clinical application of intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging to diagnose a case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) in the acute phase. RESULTS: On IVIM MR Images of this patient, higher perfusion (f) and diffusion (D) values in the left occipital and temporal lobes were found compared to the contralateral areas. CONCLUSION: These findings imply a breakdown of autoregulation with hyperperfusion and vasogenic edema during the acute phase of MELAS, as described in previous reports. IVIM imaging is a valuable, noninvasive tool that simultaneously quantifies perfusion and diffusion parameters. BlackWell Publishing Ltd 2014-11 2014-09-11 /pmc/articles/PMC4178247/ /pubmed/25365795 http://dx.doi.org/10.1002/brb3.282 Text en © 2014 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Methods
Uehara, Ryuji
Yamashita, Koji
Hiwatashi, Akio
Togao, Osamu
Kikuchi, Kazufumi
Yokoyama, Jun
Matsuse, Dai
Yoshiura, Takashi
Honda, Hiroshi
Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS: a case report
title Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS: a case report
title_full Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS: a case report
title_fullStr Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS: a case report
title_full_unstemmed Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS: a case report
title_short Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS: a case report
title_sort intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of melas: a case report
topic Methods
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178247/
https://www.ncbi.nlm.nih.gov/pubmed/25365795
http://dx.doi.org/10.1002/brb3.282
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