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Estimating intracranial volume using intracranial area in healthy children and those with childhood status epilepticus

BACKGROUND: Correcting volumetric measurements of brain structures for intracranial volume (ICV) is important in comparing volumes across subjects with different ICV. The aim of this study was to investigate whether intracranial area (ICA) reliably predicts actual ICV in a healthy pediatric cohort a...

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Autores principales: Piper, Rory J, Yoong, Michael M, Pujar, Suresh, Chin, Richard F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178250/
https://www.ncbi.nlm.nih.gov/pubmed/25365798
http://dx.doi.org/10.1002/brb3.271
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author Piper, Rory J
Yoong, Michael M
Pujar, Suresh
Chin, Richard F
author_facet Piper, Rory J
Yoong, Michael M
Pujar, Suresh
Chin, Richard F
author_sort Piper, Rory J
collection PubMed
description BACKGROUND: Correcting volumetric measurements of brain structures for intracranial volume (ICV) is important in comparing volumes across subjects with different ICV. The aim of this study was to investigate whether intracranial area (ICA) reliably predicts actual ICV in a healthy pediatric cohort and in children with convulsive status epilepticus (CSE). METHODS: T1-weighted volumetric MRI was performed on 20 healthy children (control group), 10 with CSE with structurally normal MRI (CSE/MR-), and 12 with CSE with structurally abnormal MRI (CSE/MR+). ICA, using a mid-sagittal slice, and the actual ICV were measured. RESULTS: A high Spearman correlation was found between the ICA and ICV measurements in the control (r = 0.96; P < 0.0001), CSE/MR− (r = 0.93; P = 0.0003), and CSE/MR+ (r = 0.94; P < 0.0001) groups. On comparison of predicted and actual ICV, there was no significant difference in the CSE/MR− group (P = 0.77). However, the comparison between predicted and actual ICV was significantly different in the CSE/MR+ (P = 0.001) group. Our Bland–Altman plot showed that the ICA method consistently overestimated ICV in children in the CSE/MR+ group, especially in those with small ICV or widespread structural abnormalities. CONCLUSIONS: After further validation, ICA measurement may be a reliable alternative to measuring actual ICV when correcting volume measurements for ICV, even in children with localized MRI abnormalities. Caution should be applied when the method is used in children with small ICV and those with multilobar brain pathology.
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spelling pubmed-41782502014-10-08 Estimating intracranial volume using intracranial area in healthy children and those with childhood status epilepticus Piper, Rory J Yoong, Michael M Pujar, Suresh Chin, Richard F Brain Behav Original Research BACKGROUND: Correcting volumetric measurements of brain structures for intracranial volume (ICV) is important in comparing volumes across subjects with different ICV. The aim of this study was to investigate whether intracranial area (ICA) reliably predicts actual ICV in a healthy pediatric cohort and in children with convulsive status epilepticus (CSE). METHODS: T1-weighted volumetric MRI was performed on 20 healthy children (control group), 10 with CSE with structurally normal MRI (CSE/MR-), and 12 with CSE with structurally abnormal MRI (CSE/MR+). ICA, using a mid-sagittal slice, and the actual ICV were measured. RESULTS: A high Spearman correlation was found between the ICA and ICV measurements in the control (r = 0.96; P < 0.0001), CSE/MR− (r = 0.93; P = 0.0003), and CSE/MR+ (r = 0.94; P < 0.0001) groups. On comparison of predicted and actual ICV, there was no significant difference in the CSE/MR− group (P = 0.77). However, the comparison between predicted and actual ICV was significantly different in the CSE/MR+ (P = 0.001) group. Our Bland–Altman plot showed that the ICA method consistently overestimated ICV in children in the CSE/MR+ group, especially in those with small ICV or widespread structural abnormalities. CONCLUSIONS: After further validation, ICA measurement may be a reliable alternative to measuring actual ICV when correcting volume measurements for ICV, even in children with localized MRI abnormalities. Caution should be applied when the method is used in children with small ICV and those with multilobar brain pathology. BlackWell Publishing Ltd 2014-11 2014-08-28 /pmc/articles/PMC4178250/ /pubmed/25365798 http://dx.doi.org/10.1002/brb3.271 Text en © 2014 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Piper, Rory J
Yoong, Michael M
Pujar, Suresh
Chin, Richard F
Estimating intracranial volume using intracranial area in healthy children and those with childhood status epilepticus
title Estimating intracranial volume using intracranial area in healthy children and those with childhood status epilepticus
title_full Estimating intracranial volume using intracranial area in healthy children and those with childhood status epilepticus
title_fullStr Estimating intracranial volume using intracranial area in healthy children and those with childhood status epilepticus
title_full_unstemmed Estimating intracranial volume using intracranial area in healthy children and those with childhood status epilepticus
title_short Estimating intracranial volume using intracranial area in healthy children and those with childhood status epilepticus
title_sort estimating intracranial volume using intracranial area in healthy children and those with childhood status epilepticus
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178250/
https://www.ncbi.nlm.nih.gov/pubmed/25365798
http://dx.doi.org/10.1002/brb3.271
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