Cargando…

Cyclic compressive loading on 3D tissue of human synovial fibroblasts upregulates prostaglandin E2 via COX-2 production without IL-1β and TNF-α

OBJECTIVE: Excessive mechanical stress on synovial joints causes osteoarthritis (OA) and results in the production of prostaglandin E2 (PGE2), a key molecule in arthritis, by synovial fibroblasts. However, the relationship between arthritis-related molecules and mechanical stress is still unclear. T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shimomura, K., Kanamoto, T., Kita, K., Akamine, Y., Nakamura, N., Mae, T., Yoshikawa, H., Nakata, K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	British Editorial Society of Bone and Joint Surgery 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178306/ https://www.ncbi.nlm.nih.gov/pubmed/25237168 http://dx.doi.org/10.1302/2046-3758.39.2000287

Ejemplares similares

The low molecular weight fraction of human serum albumin upregulates COX2, prostaglandin E2, and prostaglandin D2 under inflammatory conditions in osteoarthritic knee synovial fibroblasts
por: Frederick, Elizabeth D., et al.
Publicado: (2016)

Differential usage of COX-1 and COX-2 in prostaglandin production by mast cells and basophils
por: Bando, Tomoyuki, et al.
Publicado: (2017)

COX-2 metabolic products, the prostaglandin I(2) and F(2α), mediate the effects of TNF-α and Zn(2+) in stimulating the phosphorylation of Tau
por: Wang, Yue, et al.
Publicado: (2017)

The Role of COX-2 in Rheumatoid Arthritis Synovial Tissues
por: Crofford, Leslie J
Publicado: (2000)

Prostaglandin E(2 )is an enhancer for IL-1β-induced expression of membrane-associated prostaglandin E synthase in rheumatoid synovial fibroblasts
por: Kojima, F, et al.
Publicado: (2003)

Upregulation of Cyclooxygenase-2/Prostaglandin E(2) (COX-2/PGE(2)) Pathway Member Multiple Drug Resistance-Associated Protein 4 (MRP4) and Downregulation of Prostaglandin Transporter (PGT) and 15-Prostaglandin Dehydrogenase (15-PGDH) in Triple-Negative Breast Cancer
por: Kochel, Tyler J., et al.
Publicado: (2016)

Tocotrienol Attenuates Stress-Induced Gastric Lesions via Activation of Prostaglandin and Upregulation of COX-1 mRNA
por: Nur Azlina, Mohd Fahami, et al.
Publicado: (2013)

IL-1β and TNF-α Modulation of Proliferated and Committed Myoblasts: IL-6 and COX-2-Derived Prostaglandins as Key Actors in the Mechanisms Involved
por: Alvarez, Angela M., et al.
Publicado: (2020)

Choline Glycerophospholipid-Derived Prostaglandins Attenuate TNFα Gene Expression in Macrophages via a cPLA(2)α/COX-1 Pathway
por: Astudillo, Alma M., et al.
Publicado: (2021)

Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer
por: Cox, D G, et al.
Publicado: (2004)

Role of COX-2/mPGES-1/Prostaglandin E2 Cascade in Kidney Injury
por: Jia, Zhanjun, et al.
Publicado: (2015)

Effects of anti-rheumatic treatments on the prostaglandin E(2 )biosynthetic pathway in synovial tissue and synovial fluid cells from patients with rheumatoid arthritis
por: Korotkova, M, et al.
Publicado: (2005)

Upregulation of prostaglandin E(2) by inducible microsomal prostaglandin E synthase-1 in colon cancer
por: Kim, Young Hun, et al.
Publicado: (2022)

Promoting Effect of Basic Fibroblast Growth Factor in Synovial Mesenchymal Stem Cell-Based Cartilage Regeneration
por: Okamura, Gensuke, et al.
Publicado: (2020)

Rheumatoid arthritis synovial fibroblasts promote TREM-1 expression in monocytes via COX-2/PGE(2) pathway
por: Peng, Anping, et al.
Publicado: (2019)

2-Carba cyclic phosphatidic acid inhibits lipopolysaccharide-induced prostaglandin E2 production in a human macrophage cell line
por: Shibaike, Yuki, et al.
Publicado: (2019)

Prostaglandin D(2) in Inflammatory Arthritis and Its Relation with Synovial Fluid Dendritic Cells
por: Moghaddami, Mahin, et al.
Publicado: (2013)

Upregulation of PD-L1 Expression by Prostaglandin E(2) and the Enhancement of IFN-γ by Anti-PD-L1 Antibody Combined With a COX-2 Inhibitor in Mycoplasma bovis Infection
por: Goto, Shinya, et al.
Publicado: (2020)

4-Octyl-itaconate and dimethyl fumarate inhibit COX2 expression and prostaglandin production in macrophages
por: Diskin, Ciana, et al.
Publicado: (2021)

Reactive oxygen species induce Cox-2 expression via TAK1 activation in synovial fibroblast cells
por: Onodera, Yuta, et al.
Publicado: (2015)

TNF-α and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR
por: Yoo, James, et al.
Publicado: (2013)

Cyclic adenosine monophosphate response to prostaglandin E2 on subpopulations of human lymphocytes
Publicado: (1979)

COX2 is involved in hypoxia-induced TNF-α expression in osteoblast
por: Xing, Yonggang, et al.
Publicado: (2015)

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts
Publicado: (1985)

Upregulation of COX4-2 via HIF-1α in Mitochondrial COX4-1 Deficiency
por: Douiev, Liza, et al.
Publicado: (2021)

Expression of COX-1 and COX-2 in the endometrium of cyclic, pregnant and in a model of pseudopregnant rats and their regulation by sex steroids
por: St-Louis, Isabelle, et al.
Publicado: (2010)

The role of mPGES-1 for prostaglandin E(2 )production in primary human synovial cells
por: Crofford, L, et al.
Publicado: (2003)

THE DEPRESSION OF PHAGOCYTOSIS BY EXOGENOUS CYCLIC NUCLEOTIDES, PROSTAGLANDINS, AND THEOPHYLLINE
por: Cox, Joyce P., et al.
Publicado: (1973)

Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway
por: Zhang, Xing, et al.
Publicado: (2018)

Adipose mTORC1 suppresses prostaglandin signaling and beige adipogenesis via the CRTC2-COX-2 pathway
por: Zhang, Xing, et al.
Publicado: (2021)

IL-33 regulates TNF-α dependent effects in synovial fibroblasts
por: KUNISCH, ELKE, et al.
Publicado: (2012)

Pulmonary and Cardiorenal Cyclooxygenase-1 (COX-1), -2 (COX-2), and Microsomal Prostaglandin E Synthase-1 (mPGES-1) and -2 (mPGES-2) Expression in a Hypertension Model
por: Radi, Zaher A., et al.
Publicado: (2007)

ERK2 and JNK1 contribute to TNF-α-induced IL-8 expression in synovial fibroblasts
por: Namba, Shinichi, et al.
Publicado: (2017)

The Role of Prostaglandins and COX-Enzymes in Chondrogenic Differentiation of ATDC5 Progenitor Cells
por: Caron, Marjolein M. J., et al.
Publicado: (2016)

JNK activation is essential for activation of MEK/ERK signaling in IL-1β-induced COX-2 expression in synovial fibroblasts
por: Kitanaka, Taku, et al.
Publicado: (2017)

Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis
por: Sun, Haidong, et al.
Publicado: (2018)

The prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A
por: Wu, Shuangshuang, et al.
Publicado: (2020)

Curcumin Attenuates Acrolein-induced COX-2 Expression and Prostaglandin Production in Human Umbilical Vein Endothelial Cells
por: Lee, Seung Eun, et al.
Publicado: (2020)

CCN2 Mediates S1P-Induced Upregulation of COX2 Expression in Human Granulosa-Lutein Cells
por: Hu, Liao-Liao, et al.
Publicado: (2019)

Inflammation in gastric cancer: Interplay of the COX‐2/prostaglandin E(2) and Toll‐like receptor/MyD88 pathways
por: Echizen, Kanae, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_h1lmjogtj6qgu3nubmb913nrro