Cargando…

Molecular Epidemiology of Reemergent Rabies in Yunnan Province, Southwestern China

Yunnan Province in China borders 3 countries (Vietnam, Laos, and Myanmar) in Southeast Asia. In the 1980s, a large-scale rabies epidemic occurred in this province, which subsided by the late 1990s. However, 3 human cases of rabies in 2000 indicated reemergence of the disease in 1 county. In 2012, ra...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Hai-Lin, Zhang, Yu-Zhen, Yang, Wei-Hong, Tao, Xiao-Yan, Li, Hao, Ding, Ji-Chao, Feng, Yun, Yang, Du-Juan, Zhang, Juan, He, Jiang, Shen, Xin-Xin, Wang, Li-Hua, Zhang, Yun-Zhi, Song, Miao, Tang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178403/
https://www.ncbi.nlm.nih.gov/pubmed/25144604
http://dx.doi.org/10.3201/eid2009.130440
_version_ 1782336952622645248
author Zhang, Hai-Lin
Zhang, Yu-Zhen
Yang, Wei-Hong
Tao, Xiao-Yan
Li, Hao
Ding, Ji-Chao
Feng, Yun
Yang, Du-Juan
Zhang, Juan
He, Jiang
Shen, Xin-Xin
Wang, Li-Hua
Zhang, Yun-Zhi
Song, Miao
Tang, Qing
author_facet Zhang, Hai-Lin
Zhang, Yu-Zhen
Yang, Wei-Hong
Tao, Xiao-Yan
Li, Hao
Ding, Ji-Chao
Feng, Yun
Yang, Du-Juan
Zhang, Juan
He, Jiang
Shen, Xin-Xin
Wang, Li-Hua
Zhang, Yun-Zhi
Song, Miao
Tang, Qing
author_sort Zhang, Hai-Lin
collection PubMed
description Yunnan Province in China borders 3 countries (Vietnam, Laos, and Myanmar) in Southeast Asia. In the 1980s, a large-scale rabies epidemic occurred in this province, which subsided by the late 1990s. However, 3 human cases of rabies in 2000 indicated reemergence of the disease in 1 county. In 2012, rabies was detected in 77 counties; 663 persons died of rabies during this new epidemic. Fifty two rabies virus strains obtained during 2008–2012 were identified and analyzed phylogenetically by sequencing the nucleoprotein gene. Of the 4 clades identified, clades YN-A and YN-C were closely related to strains from neighboring provinces, and clade YN-B was closely related to strains from Southeast Asia, but formed a distinct branch. Rabies virus diversity might be attributed to dog movements among counties, provinces, and neighboring countries. These findings suggest that Yunnan Province is a focal point for spread of rabies between Southeast Asia and China.
format Online
Article
Text
id pubmed-4178403
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Centers for Disease Control and Prevention
record_format MEDLINE/PubMed
spelling pubmed-41784032014-09-30 Molecular Epidemiology of Reemergent Rabies in Yunnan Province, Southwestern China Zhang, Hai-Lin Zhang, Yu-Zhen Yang, Wei-Hong Tao, Xiao-Yan Li, Hao Ding, Ji-Chao Feng, Yun Yang, Du-Juan Zhang, Juan He, Jiang Shen, Xin-Xin Wang, Li-Hua Zhang, Yun-Zhi Song, Miao Tang, Qing Emerg Infect Dis Synopsis Yunnan Province in China borders 3 countries (Vietnam, Laos, and Myanmar) in Southeast Asia. In the 1980s, a large-scale rabies epidemic occurred in this province, which subsided by the late 1990s. However, 3 human cases of rabies in 2000 indicated reemergence of the disease in 1 county. In 2012, rabies was detected in 77 counties; 663 persons died of rabies during this new epidemic. Fifty two rabies virus strains obtained during 2008–2012 were identified and analyzed phylogenetically by sequencing the nucleoprotein gene. Of the 4 clades identified, clades YN-A and YN-C were closely related to strains from neighboring provinces, and clade YN-B was closely related to strains from Southeast Asia, but formed a distinct branch. Rabies virus diversity might be attributed to dog movements among counties, provinces, and neighboring countries. These findings suggest that Yunnan Province is a focal point for spread of rabies between Southeast Asia and China. Centers for Disease Control and Prevention 2014-09 /pmc/articles/PMC4178403/ /pubmed/25144604 http://dx.doi.org/10.3201/eid2009.130440 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Synopsis
Zhang, Hai-Lin
Zhang, Yu-Zhen
Yang, Wei-Hong
Tao, Xiao-Yan
Li, Hao
Ding, Ji-Chao
Feng, Yun
Yang, Du-Juan
Zhang, Juan
He, Jiang
Shen, Xin-Xin
Wang, Li-Hua
Zhang, Yun-Zhi
Song, Miao
Tang, Qing
Molecular Epidemiology of Reemergent Rabies in Yunnan Province, Southwestern China
title Molecular Epidemiology of Reemergent Rabies in Yunnan Province, Southwestern China
title_full Molecular Epidemiology of Reemergent Rabies in Yunnan Province, Southwestern China
title_fullStr Molecular Epidemiology of Reemergent Rabies in Yunnan Province, Southwestern China
title_full_unstemmed Molecular Epidemiology of Reemergent Rabies in Yunnan Province, Southwestern China
title_short Molecular Epidemiology of Reemergent Rabies in Yunnan Province, Southwestern China
title_sort molecular epidemiology of reemergent rabies in yunnan province, southwestern china
topic Synopsis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178403/
https://www.ncbi.nlm.nih.gov/pubmed/25144604
http://dx.doi.org/10.3201/eid2009.130440
work_keys_str_mv AT zhanghailin molecularepidemiologyofreemergentrabiesinyunnanprovincesouthwesternchina
AT zhangyuzhen molecularepidemiologyofreemergentrabiesinyunnanprovincesouthwesternchina
AT yangweihong molecularepidemiologyofreemergentrabiesinyunnanprovincesouthwesternchina
AT taoxiaoyan molecularepidemiologyofreemergentrabiesinyunnanprovincesouthwesternchina
AT lihao molecularepidemiologyofreemergentrabiesinyunnanprovincesouthwesternchina
AT dingjichao molecularepidemiologyofreemergentrabiesinyunnanprovincesouthwesternchina
AT fengyun molecularepidemiologyofreemergentrabiesinyunnanprovincesouthwesternchina
AT yangdujuan molecularepidemiologyofreemergentrabiesinyunnanprovincesouthwesternchina
AT zhangjuan molecularepidemiologyofreemergentrabiesinyunnanprovincesouthwesternchina
AT hejiang molecularepidemiologyofreemergentrabiesinyunnanprovincesouthwesternchina
AT shenxinxin molecularepidemiologyofreemergentrabiesinyunnanprovincesouthwesternchina
AT wanglihua molecularepidemiologyofreemergentrabiesinyunnanprovincesouthwesternchina
AT zhangyunzhi molecularepidemiologyofreemergentrabiesinyunnanprovincesouthwesternchina
AT songmiao molecularepidemiologyofreemergentrabiesinyunnanprovincesouthwesternchina
AT tangqing molecularepidemiologyofreemergentrabiesinyunnanprovincesouthwesternchina