An Improved High Yield Total Synthesis and Cytotoxicity Study of the Marine Alkaloid Neoamphimedine: An ATP-Competitive Inhibitor of Topoisomerase IIα and Potent Anticancer Agent

Recently, we characterized neoamphimedine (neo) as an ATP-competitive inhibitor of the ATPase domain of human Topoisomerase IIα. Thus far, neo is the only pyridoacridine with this mechanism of action. One limiting factor in the development of neo as a therapeutic agent has been access to sufficient...

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Detalles Bibliográficos
Autores principales: Li, Linfeng, Abraham, Adedoyin D., Zhou, Qiong, Ali, Hadi, O’Brien, Jeremy V., Hamill, Brayden D., Arcaroli, John J., Messersmith, Wells A., LaBarbera, Daniel V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178486/
https://www.ncbi.nlm.nih.gov/pubmed/25244109
http://dx.doi.org/10.3390/md12094833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178486/
https://www.ncbi.nlm.nih.gov/pubmed/25244109
http://dx.doi.org/10.3390/md12094833

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