Multiple Components of the VHL Tumor Suppressor Complex Are Frequently Affected by DNA Copy Number Loss in Pheochromocytoma

Pheochromocytomas (PCC) are rare tumors that arise in chromaffin tissue of the adrenal gland. PCC are frequently inherited through predisposing mutations in genes such as the von Hippel-Lindau (VHL) tumor suppressor. VHL is part of the VHL elongin BC protein complex that also includes CUL2/5, TCEB1,...

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Detalles Bibliográficos
Autores principales: Rowbotham, David A., Enfield, Katey S. S., Martinez, Victor D., Thu, Kelsie L., Vucic, Emily A., Stewart, Greg L., Bennewith, Kevin L., Lam, Wan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178909/
https://www.ncbi.nlm.nih.gov/pubmed/25298778
http://dx.doi.org/10.1155/2014/546347

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