Cargando…

Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity

Rat and mouse adrenal medullary chromaffin cells (CCs) express an inactivating BK current. This inactivation is thought to arise from the assembly of up to four β2 auxiliary subunits (encoded by the kcnmb2 gene) with a tetramer of pore-forming Slo1 α subunits. Although the physiological consequences...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martinez-Espinosa, Pedro L., Yang, Chengtao, Gonzalez-Perez, Vivian, Xia, Xiao-Ming, Lingle, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2014
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178941/ https://www.ncbi.nlm.nih.gov/pubmed/25267913 http://dx.doi.org/10.1085/jgp.201411253

Ejemplares similares

Fast inactivation of Nav current in rat adrenal chromaffin cells involves two independent inactivation pathways
por: Martinez-Espinosa, Pedro L., et al.
Publicado: (2021)

Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating
por: Gonzalez-Perez, Vivian, et al.
Publicado: (2015)

Stereospecific binding of a disordered peptide segment mediates BK channel inactivation
por: Gonzalez-Perez, Vivian, et al.
Publicado: (2012)

Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells
por: Martinez-Espinosa, Pedro L., et al.
Publicado: (2021)

N-terminal Inactivation Domains of β Subunits Are Protected from Trypsin Digestion by Binding within the Antechamber of BK Channels
por: Zhang, Zhe, et al.
Publicado: (2009)

Knockout of the BK β2 subunit reveals the importance of accessorizing your channel
por: Brenner, Robert
Publicado: (2014)

Direct Observation of a Preinactivated, Open State in BK Channels with β2 Subunits
por: Benzinger, G. Richard, et al.
Publicado: (2006)

Glycine(311), a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix
por: Zhou, Yu, et al.
Publicado: (2010)

Inactivation of BK Channels by the NH(2) Terminus of the β2 Auxiliary Subunit: An Essential Role of a Terminal Peptide Segment of Three Hydrophobic Residues
por: Xia, Xiao-Ming, et al.
Publicado: (2003)

BK channel inhibition by strong extracellular acidification
por: Zhou, Yu, et al.
Publicado: (2018)

Knockout of Slo2.2 enhances itch, abolishes K(Na) current, and increases action potential firing frequency in DRG neurons
por: Martinez-Espinosa, Pedro L, et al.
Publicado: (2015)

Setting the Stage for Molecular Dissection of the Regulatory Components of BK Channels
por: Lingle, Christopher J.
Publicado: (2002)

Mg(2+)-dependent Regulation of BK Channels: Importance of Electrostatics
por: Lingle, Christopher J.
Publicado: (2008)

Regulation of BK channels by auxiliary γ subunits
por: Zhang, Jiyuan, et al.
Publicado: (2014)

Permissive Modulation of Sphingosine-1-Phosphate-Enhanced Intracellular Calcium on BK(Ca) Channel of Chromaffin Cells
por: Wu, Adonis Z., et al.
Publicado: (2021)

Measuring the Influence of the BK(Ca) β1 Subunit on Ca(2+) Binding to the BK(Ca) Channel
por: Sweet, Tara-Beth, et al.
Publicado: (2009)

Inactivation of Bk Channels Mediated by the Nh(2) Terminus of the β3b Auxiliary Subunit Involves a Two-Step Mechanism: Possible Separation of Binding and Blockade
por: Lingle, Christopher J., et al.
Publicado: (2001)

Mechanism of β4 Subunit Modulation of BK Channels
por: Wang, Bin, et al.
Publicado: (2006)

Location of modulatory β subunits in BK potassium channels
por: Liu, Guoxia, et al.
Publicado: (2010)

Trafficking of BK channel subunits controls arterial contractility
por: Leo, M. Dennis, et al.
Publicado: (2017)

Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism
por: Zhou, Yu, et al.
Publicado: (2014)

Species-specific Differences among KCNMB3 BK β3 Auxiliary Subunits: Some β3 N-terminal Variants May Be Primate-specific Subunits
por: Zeng, Xuhui, et al.
Publicado: (2008)

Gating Properties Conferred on Bk Channels by the β3b Auxiliary Subunit in the Absence of Its Nh(2)- and Cooh Termini
por: Zeng, Xu-Hui, et al.
Publicado: (2001)

Both Transmembrane Domains of BK β1 Subunits Are Essential to Confer the Normal Phenotype of β1-Containing BK Channels
por: Kuntamallappanavar, Guruprasad, et al.
Publicado: (2014)

Modes of Operation of the BK(Ca) Channel β(2) Subunit
por: Savalli, Nicoletta, et al.
Publicado: (2007)

BK channel inactivation gates daytime excitability in the circadian clock
por: Whitt, Joshua P., et al.
Publicado: (2016)

Inter-α/β subunits coupling mediating pre-inactivation and augmented activation of BK(Ca)(β2)
por: Hou, Panpan, et al.
Publicado: (2013)

Closed-channel block of BK potassium channels by bbTBA requires partial activation
por: Tang, Qiong-Yao, et al.
Publicado: (2009)

BK Virus and Transplantation
por: Prezioso, Carla, et al.
Publicado: (2021)

Pharmacological consequences of the coexpression of BK channel α and auxiliary β subunits
por: Torres, Yolima P., et al.
Publicado: (2014)

Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation
por: Guan, Xin, et al.
Publicado: (2017)

Alcohol modulation of BK channel gating depends on β subunit composition
por: Kuntamallappanavar, Guruprasad, et al.
Publicado: (2016)

BK Channel in the Physiology and in the Cancer of Pancreatic Duct: Impact and Reliability of BK Openers
por: Zuccolini, Paolo, et al.
Publicado: (2022)

BK Virus Infection and BK-Virus-Associated Nephropathy in Renal Transplant Recipients
por: Borriello, Margherita, et al.
Publicado: (2022)

CORRIGENDUM: Inter-α/β subunits coupling mediating pre-inactivation and augmented activation of BK(Ca)(β2)
por: Hou, Panpan, et al.
Publicado: (2013)

Divalent Cation Sensitivity of BK Channel Activation Supports the Existence of Three Distinct Binding Sites
por: Zeng, Xu-Hui, et al.
Publicado: (2005)

Progression from Sustained BK Viruria to Sustained BK Viremia with Immunosuppression Reduction Is Not Associated with Changes in the Noncoding Control Region of the BK Virus Genome
por: Memon, Imran A., et al.
Publicado: (2012)

BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection
por: Vigil, Darlene, et al.
Publicado: (2016)

BK Virus Replication in the Glomerular Vascular Unit: Implications for BK Virus Associated Nephropathy
por: Popik, Waldemar, et al.
Publicado: (2019)

Optimal use of plasma and urine BK viral loads for screening and predicting BK nephropathy
por: Boan, Peter, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_qcf0up4h7koqpshg4df81c2rf3