A sharp end to sugary Wingless travels

Drosophila melanogaster follicle stem cells are controlled by Wingless (Wg) ligands secreted 50 µm away, raising the question of how long-distance Wg spreading occurs. In this issue of JCB, Wang and Page-McCaw (2014. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201403084) demonstrate a potential mech...

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Detalles Bibliográficos
Autores principales: Droujinine, Ilia A., Yan, Dong, Perrimon, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178964/
https://www.ncbi.nlm.nih.gov/pubmed/25267292
http://dx.doi.org/10.1083/jcb.201408115
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author Droujinine, Ilia A.
Yan, Dong
Perrimon, Norbert
author_facet Droujinine, Ilia A.
Yan, Dong
Perrimon, Norbert
author_sort Droujinine, Ilia A.
collection PubMed
description Drosophila melanogaster follicle stem cells are controlled by Wingless (Wg) ligands secreted 50 µm away, raising the question of how long-distance Wg spreading occurs. In this issue of JCB, Wang and Page-McCaw (2014. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201403084) demonstrate a potential mechanism by which the heparan sulfate proteoglycan Dally-like (Dlp) promotes Wg travel, whereas matrix Mmp2 (Metalloproteinase 2) impedes it by inactivating Dlp.
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spelling pubmed-41789642015-03-29 A sharp end to sugary Wingless travels Droujinine, Ilia A. Yan, Dong Perrimon, Norbert J Cell Biol Reviews Drosophila melanogaster follicle stem cells are controlled by Wingless (Wg) ligands secreted 50 µm away, raising the question of how long-distance Wg spreading occurs. In this issue of JCB, Wang and Page-McCaw (2014. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201403084) demonstrate a potential mechanism by which the heparan sulfate proteoglycan Dally-like (Dlp) promotes Wg travel, whereas matrix Mmp2 (Metalloproteinase 2) impedes it by inactivating Dlp. The Rockefeller University Press 2014-09-29 /pmc/articles/PMC4178964/ /pubmed/25267292 http://dx.doi.org/10.1083/jcb.201408115 Text en © 2014 Droujinine et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Droujinine, Ilia A.
Yan, Dong
Perrimon, Norbert
A sharp end to sugary Wingless travels
title A sharp end to sugary Wingless travels
title_full A sharp end to sugary Wingless travels
title_fullStr A sharp end to sugary Wingless travels
title_full_unstemmed A sharp end to sugary Wingless travels
title_short A sharp end to sugary Wingless travels
title_sort sharp end to sugary wingless travels
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178964/
https://www.ncbi.nlm.nih.gov/pubmed/25267292
http://dx.doi.org/10.1083/jcb.201408115
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