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Recent Developments in Optical Detection Technologies in Lab-on-a-Chip Devices for Biosensing Applications

The field of microfluidics has yet to develop practical devices that provide real clinical value. One of the main reasons for this is the difficulty in realizing low-cost, sensitive, reproducible, and portable analyte detection microfluidic systems. Previous research has addressed two main approache...

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Autores principales: Pires, Nuno Miguel Matos, Dong, Tao, Hanke, Ulrik, Hoivik, Nils
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178989/
https://www.ncbi.nlm.nih.gov/pubmed/25196161
http://dx.doi.org/10.3390/s140815458
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author Pires, Nuno Miguel Matos
Dong, Tao
Hanke, Ulrik
Hoivik, Nils
author_facet Pires, Nuno Miguel Matos
Dong, Tao
Hanke, Ulrik
Hoivik, Nils
author_sort Pires, Nuno Miguel Matos
collection PubMed
description The field of microfluidics has yet to develop practical devices that provide real clinical value. One of the main reasons for this is the difficulty in realizing low-cost, sensitive, reproducible, and portable analyte detection microfluidic systems. Previous research has addressed two main approaches for the detection technologies in lab-on-a-chip devices: (a) study of the compatibility of conventional instrumentation with microfluidic structures, and (b) integration of innovative sensors contained within the microfluidic system. Despite the recent advances in electrochemical and mechanical based sensors, their drawbacks pose important challenges to their application in disposable microfluidic devices. Instead, optical detection remains an attractive solution for lab-on-a-chip devices, because of the ubiquity of the optical methods in the laboratory. Besides, robust and cost-effective devices for use in the field can be realized by integrating proper optical detection technologies on chips. This review examines the recent developments in detection technologies applied to microfluidic biosensors, especially addressing several optical methods, including fluorescence, chemiluminescence, absorbance and surface plasmon resonance.
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spelling pubmed-41789892014-10-02 Recent Developments in Optical Detection Technologies in Lab-on-a-Chip Devices for Biosensing Applications Pires, Nuno Miguel Matos Dong, Tao Hanke, Ulrik Hoivik, Nils Sensors (Basel) Review The field of microfluidics has yet to develop practical devices that provide real clinical value. One of the main reasons for this is the difficulty in realizing low-cost, sensitive, reproducible, and portable analyte detection microfluidic systems. Previous research has addressed two main approaches for the detection technologies in lab-on-a-chip devices: (a) study of the compatibility of conventional instrumentation with microfluidic structures, and (b) integration of innovative sensors contained within the microfluidic system. Despite the recent advances in electrochemical and mechanical based sensors, their drawbacks pose important challenges to their application in disposable microfluidic devices. Instead, optical detection remains an attractive solution for lab-on-a-chip devices, because of the ubiquity of the optical methods in the laboratory. Besides, robust and cost-effective devices for use in the field can be realized by integrating proper optical detection technologies on chips. This review examines the recent developments in detection technologies applied to microfluidic biosensors, especially addressing several optical methods, including fluorescence, chemiluminescence, absorbance and surface plasmon resonance. MDPI 2014-08-21 /pmc/articles/PMC4178989/ /pubmed/25196161 http://dx.doi.org/10.3390/s140815458 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Pires, Nuno Miguel Matos
Dong, Tao
Hanke, Ulrik
Hoivik, Nils
Recent Developments in Optical Detection Technologies in Lab-on-a-Chip Devices for Biosensing Applications
title Recent Developments in Optical Detection Technologies in Lab-on-a-Chip Devices for Biosensing Applications
title_full Recent Developments in Optical Detection Technologies in Lab-on-a-Chip Devices for Biosensing Applications
title_fullStr Recent Developments in Optical Detection Technologies in Lab-on-a-Chip Devices for Biosensing Applications
title_full_unstemmed Recent Developments in Optical Detection Technologies in Lab-on-a-Chip Devices for Biosensing Applications
title_short Recent Developments in Optical Detection Technologies in Lab-on-a-Chip Devices for Biosensing Applications
title_sort recent developments in optical detection technologies in lab-on-a-chip devices for biosensing applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178989/
https://www.ncbi.nlm.nih.gov/pubmed/25196161
http://dx.doi.org/10.3390/s140815458
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