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Coffee Consumption and Risk of Gastric Cancer: A Large Updated Meta-Analysis of Prospective Studies

The potential role of coffee consumption in the development of various types of cancer has been extensively investigated in epidemiologic studies. How coffee consumption may modulate risk of gastric cancer, however, remains a subject open for investigation. To better quantify this relation, we quant...

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Detalles Bibliográficos
Autores principales: Xie, Feiyue, Wang, Dan, Huang, Zhifang, Guo, Yajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179186/
https://www.ncbi.nlm.nih.gov/pubmed/25237829
http://dx.doi.org/10.3390/nu6093734
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author Xie, Feiyue
Wang, Dan
Huang, Zhifang
Guo, Yajun
author_facet Xie, Feiyue
Wang, Dan
Huang, Zhifang
Guo, Yajun
author_sort Xie, Feiyue
collection PubMed
description The potential role of coffee consumption in the development of various types of cancer has been extensively investigated in epidemiologic studies. How coffee consumption may modulate risk of gastric cancer, however, remains a subject open for investigation. To better quantify this relation, we quantitatively summarized evidence from prospective studies. Eligible studies were identified on PubMed databases. The summary risk estimates were obtained using the random-effects model. Subgroup, sensitivity and dose-response analyses were conducted. The present meta-analysis included 12 prospective cohort studies. A pooled analysis of these studies suggested that coffee consumption (highest vs. lowest consumption) was not associated with risk of gastric cancer (RR = 1.12, 95% CI = 0.93–1.36). In the subgroup analysis, significant increased risk was detected in the U.S. studies (RR = 1.36, 95% CI = 1.06–1.74) and in the studies with <10 years of follow-up (RR = 1.24, 95% CI = 1.00–1.54), and the greatest increase in risk was observed in those studies without adjustment for smoking (RR = 1.48, 95% CI = 1.13–1.93). There was some evidence of publication bias (P for Egger’s test = 0.03). Cumulative evidence from prospective studies suggests that coffee consumption is not associated with risk of gastric cancer. The observed positive results may be confounded by smoking and need further investigation.
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spelling pubmed-41791862014-10-02 Coffee Consumption and Risk of Gastric Cancer: A Large Updated Meta-Analysis of Prospective Studies Xie, Feiyue Wang, Dan Huang, Zhifang Guo, Yajun Nutrients Article The potential role of coffee consumption in the development of various types of cancer has been extensively investigated in epidemiologic studies. How coffee consumption may modulate risk of gastric cancer, however, remains a subject open for investigation. To better quantify this relation, we quantitatively summarized evidence from prospective studies. Eligible studies were identified on PubMed databases. The summary risk estimates were obtained using the random-effects model. Subgroup, sensitivity and dose-response analyses were conducted. The present meta-analysis included 12 prospective cohort studies. A pooled analysis of these studies suggested that coffee consumption (highest vs. lowest consumption) was not associated with risk of gastric cancer (RR = 1.12, 95% CI = 0.93–1.36). In the subgroup analysis, significant increased risk was detected in the U.S. studies (RR = 1.36, 95% CI = 1.06–1.74) and in the studies with <10 years of follow-up (RR = 1.24, 95% CI = 1.00–1.54), and the greatest increase in risk was observed in those studies without adjustment for smoking (RR = 1.48, 95% CI = 1.13–1.93). There was some evidence of publication bias (P for Egger’s test = 0.03). Cumulative evidence from prospective studies suggests that coffee consumption is not associated with risk of gastric cancer. The observed positive results may be confounded by smoking and need further investigation. MDPI 2014-09-18 /pmc/articles/PMC4179186/ /pubmed/25237829 http://dx.doi.org/10.3390/nu6093734 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Xie, Feiyue
Wang, Dan
Huang, Zhifang
Guo, Yajun
Coffee Consumption and Risk of Gastric Cancer: A Large Updated Meta-Analysis of Prospective Studies
title Coffee Consumption and Risk of Gastric Cancer: A Large Updated Meta-Analysis of Prospective Studies
title_full Coffee Consumption and Risk of Gastric Cancer: A Large Updated Meta-Analysis of Prospective Studies
title_fullStr Coffee Consumption and Risk of Gastric Cancer: A Large Updated Meta-Analysis of Prospective Studies
title_full_unstemmed Coffee Consumption and Risk of Gastric Cancer: A Large Updated Meta-Analysis of Prospective Studies
title_short Coffee Consumption and Risk of Gastric Cancer: A Large Updated Meta-Analysis of Prospective Studies
title_sort coffee consumption and risk of gastric cancer: a large updated meta-analysis of prospective studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179186/
https://www.ncbi.nlm.nih.gov/pubmed/25237829
http://dx.doi.org/10.3390/nu6093734
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