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Does Vitamin C Deficiency Affect Cognitive Development and Function?
Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(−/−) mice...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179190/ https://www.ncbi.nlm.nih.gov/pubmed/25244370 http://dx.doi.org/10.3390/nu6093818 |
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author | Hansen, Stine Normann Tveden-Nyborg, Pernille Lykkesfeldt, Jens |
author_facet | Hansen, Stine Normann Tveden-Nyborg, Pernille Lykkesfeldt, Jens |
author_sort | Hansen, Stine Normann |
collection | PubMed |
description | Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(−/−) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies. |
format | Online Article Text |
id | pubmed-4179190 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-41791902014-10-02 Does Vitamin C Deficiency Affect Cognitive Development and Function? Hansen, Stine Normann Tveden-Nyborg, Pernille Lykkesfeldt, Jens Nutrients Review Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(−/−) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies. MDPI 2014-09-19 /pmc/articles/PMC4179190/ /pubmed/25244370 http://dx.doi.org/10.3390/nu6093818 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Hansen, Stine Normann Tveden-Nyborg, Pernille Lykkesfeldt, Jens Does Vitamin C Deficiency Affect Cognitive Development and Function? |
title | Does Vitamin C Deficiency Affect Cognitive Development and Function? |
title_full | Does Vitamin C Deficiency Affect Cognitive Development and Function? |
title_fullStr | Does Vitamin C Deficiency Affect Cognitive Development and Function? |
title_full_unstemmed | Does Vitamin C Deficiency Affect Cognitive Development and Function? |
title_short | Does Vitamin C Deficiency Affect Cognitive Development and Function? |
title_sort | does vitamin c deficiency affect cognitive development and function? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179190/ https://www.ncbi.nlm.nih.gov/pubmed/25244370 http://dx.doi.org/10.3390/nu6093818 |
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