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Does Vitamin C Deficiency Affect Cognitive Development and Function?

Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(−/−) mice...

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Autores principales: Hansen, Stine Normann, Tveden-Nyborg, Pernille, Lykkesfeldt, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179190/
https://www.ncbi.nlm.nih.gov/pubmed/25244370
http://dx.doi.org/10.3390/nu6093818
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author Hansen, Stine Normann
Tveden-Nyborg, Pernille
Lykkesfeldt, Jens
author_facet Hansen, Stine Normann
Tveden-Nyborg, Pernille
Lykkesfeldt, Jens
author_sort Hansen, Stine Normann
collection PubMed
description Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(−/−) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies.
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spelling pubmed-41791902014-10-02 Does Vitamin C Deficiency Affect Cognitive Development and Function? Hansen, Stine Normann Tveden-Nyborg, Pernille Lykkesfeldt, Jens Nutrients Review Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(−/−) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies. MDPI 2014-09-19 /pmc/articles/PMC4179190/ /pubmed/25244370 http://dx.doi.org/10.3390/nu6093818 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Hansen, Stine Normann
Tveden-Nyborg, Pernille
Lykkesfeldt, Jens
Does Vitamin C Deficiency Affect Cognitive Development and Function?
title Does Vitamin C Deficiency Affect Cognitive Development and Function?
title_full Does Vitamin C Deficiency Affect Cognitive Development and Function?
title_fullStr Does Vitamin C Deficiency Affect Cognitive Development and Function?
title_full_unstemmed Does Vitamin C Deficiency Affect Cognitive Development and Function?
title_short Does Vitamin C Deficiency Affect Cognitive Development and Function?
title_sort does vitamin c deficiency affect cognitive development and function?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179190/
https://www.ncbi.nlm.nih.gov/pubmed/25244370
http://dx.doi.org/10.3390/nu6093818
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