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Iron, Oxidative Stress and Gestational Diabetes
Both iron deficiency and hyperglycemia are highly prevalent globally for pregnant women. Iron supplementation is recommended during pregnancy to control iron deficiency. The purposes of the review are to assess the oxidative effects of iron supplementation and the potential relationship between iron...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179198/ https://www.ncbi.nlm.nih.gov/pubmed/25255832 http://dx.doi.org/10.3390/nu6093968 |
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author | Zhuang, Taifeng Han, Huijun Yang, Zhenyu |
author_facet | Zhuang, Taifeng Han, Huijun Yang, Zhenyu |
author_sort | Zhuang, Taifeng |
collection | PubMed |
description | Both iron deficiency and hyperglycemia are highly prevalent globally for pregnant women. Iron supplementation is recommended during pregnancy to control iron deficiency. The purposes of the review are to assess the oxidative effects of iron supplementation and the potential relationship between iron nutrition and gestational diabetes. High doses of iron (~relative to 60 mg or more daily for adult humans) can induce lipid peroxidation in vitro and in animal studies. Pharmaceutical doses of iron supplements (e.g., 10× RDA or more for oral supplements or direct iron supplementation via injection or addition to the cell culture medium) for a short or long duration will induce DNA damage. Higher heme-iron intake or iron status measured by various biomarkers, especially serum ferritin, might contribute to greater risk of gestational diabetes, which may be mediated by iron oxidative stress though lipid oxidation and/or DNA damage. However, information is lacking about the effect of low dose iron supplementation (≤60 mg daily) on lipid peroxidation, DNA damage and gestational diabetes. Randomized trials of low-dose iron supplementation (≤60 mg daily) for pregnant women are warranted to test the relationship between iron oxidative stress and insulin resistance/gestational diabetes, especially for iron-replete women. |
format | Online Article Text |
id | pubmed-4179198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-41791982014-10-02 Iron, Oxidative Stress and Gestational Diabetes Zhuang, Taifeng Han, Huijun Yang, Zhenyu Nutrients Review Both iron deficiency and hyperglycemia are highly prevalent globally for pregnant women. Iron supplementation is recommended during pregnancy to control iron deficiency. The purposes of the review are to assess the oxidative effects of iron supplementation and the potential relationship between iron nutrition and gestational diabetes. High doses of iron (~relative to 60 mg or more daily for adult humans) can induce lipid peroxidation in vitro and in animal studies. Pharmaceutical doses of iron supplements (e.g., 10× RDA or more for oral supplements or direct iron supplementation via injection or addition to the cell culture medium) for a short or long duration will induce DNA damage. Higher heme-iron intake or iron status measured by various biomarkers, especially serum ferritin, might contribute to greater risk of gestational diabetes, which may be mediated by iron oxidative stress though lipid oxidation and/or DNA damage. However, information is lacking about the effect of low dose iron supplementation (≤60 mg daily) on lipid peroxidation, DNA damage and gestational diabetes. Randomized trials of low-dose iron supplementation (≤60 mg daily) for pregnant women are warranted to test the relationship between iron oxidative stress and insulin resistance/gestational diabetes, especially for iron-replete women. MDPI 2014-09-25 /pmc/articles/PMC4179198/ /pubmed/25255832 http://dx.doi.org/10.3390/nu6093968 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Zhuang, Taifeng Han, Huijun Yang, Zhenyu Iron, Oxidative Stress and Gestational Diabetes |
title | Iron, Oxidative Stress and Gestational Diabetes |
title_full | Iron, Oxidative Stress and Gestational Diabetes |
title_fullStr | Iron, Oxidative Stress and Gestational Diabetes |
title_full_unstemmed | Iron, Oxidative Stress and Gestational Diabetes |
title_short | Iron, Oxidative Stress and Gestational Diabetes |
title_sort | iron, oxidative stress and gestational diabetes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179198/ https://www.ncbi.nlm.nih.gov/pubmed/25255832 http://dx.doi.org/10.3390/nu6093968 |
work_keys_str_mv | AT zhuangtaifeng ironoxidativestressandgestationaldiabetes AT hanhuijun ironoxidativestressandgestationaldiabetes AT yangzhenyu ironoxidativestressandgestationaldiabetes |