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Physiological Epidermal Growth Factor Concentrations Activate High Affinity Receptors to Elicit Calcium Oscillations

Signaling mediated by the epidermal growth factor (EGF) is crucial in tissue development, homeostasis and tumorigenesis. EGF is mitogenic at picomolar concentrations and is known to bind its receptor on high affinity binding sites depending of the oligomerization state of the receptor (monomer or di...

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Detalles Bibliográficos
Autores principales:	Marquèze-Pouey, Béatrice, Mailfert, Sébastien, Rouger, Vincent, Goaillard, Jean-Marc, Marguet, Didier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179260/ https://www.ncbi.nlm.nih.gov/pubmed/25265278 http://dx.doi.org/10.1371/journal.pone.0106803

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