A Short History of the B-Cell-Associated Surface Molecule CD40

This perspective traces developments using monoclonal antibody technology that led to the discovery of CD40, a receptor that on B cells mediates “T cell help” and on dendritic cells helps to program CD8 T cell responses. I discuss some things that we got right during the path of discovery and some t...

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Detalles Bibliográficos
Autor principal: Clark, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179537/
https://www.ncbi.nlm.nih.gov/pubmed/25324844
http://dx.doi.org/10.3389/fimmu.2014.00472
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author Clark, Edward A.
author_facet Clark, Edward A.
author_sort Clark, Edward A.
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description This perspective traces developments using monoclonal antibody technology that led to the discovery of CD40, a receptor that on B cells mediates “T cell help” and on dendritic cells helps to program CD8 T cell responses. I discuss some things that we got right during the path of discovery and some things we missed. Immunotherapies that block or stimulate the CD40 pathway hold great promise for treatment of autoimmune diseases and cancers.
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spelling pubmed-41795372014-10-16 A Short History of the B-Cell-Associated Surface Molecule CD40 Clark, Edward A. Front Immunol Immunology This perspective traces developments using monoclonal antibody technology that led to the discovery of CD40, a receptor that on B cells mediates “T cell help” and on dendritic cells helps to program CD8 T cell responses. I discuss some things that we got right during the path of discovery and some things we missed. Immunotherapies that block or stimulate the CD40 pathway hold great promise for treatment of autoimmune diseases and cancers. Frontiers Media S.A. 2014-09-29 /pmc/articles/PMC4179537/ /pubmed/25324844 http://dx.doi.org/10.3389/fimmu.2014.00472 Text en Copyright © 2014 Clark. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Clark, Edward A.
A Short History of the B-Cell-Associated Surface Molecule CD40
title A Short History of the B-Cell-Associated Surface Molecule CD40
title_full A Short History of the B-Cell-Associated Surface Molecule CD40
title_fullStr A Short History of the B-Cell-Associated Surface Molecule CD40
title_full_unstemmed A Short History of the B-Cell-Associated Surface Molecule CD40
title_short A Short History of the B-Cell-Associated Surface Molecule CD40
title_sort short history of the b-cell-associated surface molecule cd40
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179537/
https://www.ncbi.nlm.nih.gov/pubmed/25324844
http://dx.doi.org/10.3389/fimmu.2014.00472
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