Macroautophagy and the Oncogene-Induced Senescence

The oncogene-induced senescence is emerging as a potent tumor suppressor mechanism and as a possible therapeutic target. Macroautophagy is intimately linked to the senescence condition setup, although its role has not been elucidated yet. Here, we discuss up-to-date concepts of senescence-related ma...

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Detalles Bibliográficos
Autores principales: Grasso, Daniel, Vaccaro, Maria I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179625/
https://www.ncbi.nlm.nih.gov/pubmed/25324830
http://dx.doi.org/10.3389/fendo.2014.00157
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author Grasso, Daniel
Vaccaro, Maria I.
author_facet Grasso, Daniel
Vaccaro, Maria I.
author_sort Grasso, Daniel
collection PubMed
description The oncogene-induced senescence is emerging as a potent tumor suppressor mechanism and as a possible therapeutic target. Macroautophagy is intimately linked to the senescence condition setup, although its role has not been elucidated yet. Here, we discuss up-to-date concepts of senescence-related macroautophagy and evaluate the current trend of this growing research field, which has relevance in future perspectives toward therapeutic options against cancer.
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spelling pubmed-41796252014-10-16 Macroautophagy and the Oncogene-Induced Senescence Grasso, Daniel Vaccaro, Maria I. Front Endocrinol (Lausanne) Endocrinology The oncogene-induced senescence is emerging as a potent tumor suppressor mechanism and as a possible therapeutic target. Macroautophagy is intimately linked to the senescence condition setup, although its role has not been elucidated yet. Here, we discuss up-to-date concepts of senescence-related macroautophagy and evaluate the current trend of this growing research field, which has relevance in future perspectives toward therapeutic options against cancer. Frontiers Media S.A. 2014-09-29 /pmc/articles/PMC4179625/ /pubmed/25324830 http://dx.doi.org/10.3389/fendo.2014.00157 Text en Copyright © 2014 Grasso and Vaccaro. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Grasso, Daniel
Vaccaro, Maria I.
Macroautophagy and the Oncogene-Induced Senescence
title Macroautophagy and the Oncogene-Induced Senescence
title_full Macroautophagy and the Oncogene-Induced Senescence
title_fullStr Macroautophagy and the Oncogene-Induced Senescence
title_full_unstemmed Macroautophagy and the Oncogene-Induced Senescence
title_short Macroautophagy and the Oncogene-Induced Senescence
title_sort macroautophagy and the oncogene-induced senescence
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179625/
https://www.ncbi.nlm.nih.gov/pubmed/25324830
http://dx.doi.org/10.3389/fendo.2014.00157
work_keys_str_mv AT grassodaniel macroautophagyandtheoncogeneinducedsenescence
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