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Ubiquitin–proteasome system involvement in Huntington’s disease

Huntington’s disease (HD) is a genetic autosomal dominant neurodegenerative disease caused by the expansion of a CAG repeat in the huntingtin (htt) gene. This triplet expansion encodes a polyglutamine stretch (polyQ) in the N-terminus of the high molecular weight (348-kDa) and ubiquitously expressed...

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Detalles Bibliográficos
Autores principales:	Ortega, Zaira, Lucas, Jose J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179678/ https://www.ncbi.nlm.nih.gov/pubmed/25324717 http://dx.doi.org/10.3389/fnmol.2014.00077

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