Potential of caveolae in the therapy of cardiovascular and neurological diseases

Caveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with a hairpin-like structure. Caveolae participate in receptor-mediated trafficking of cell surface receptors and receptor-mediated signaling. Furthermore, caveolae participate...

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Autores principales: Navarro, Gemma, Borroto-Escuela, Dasiel O., Fuxe, Kjell, Franco, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179688/
https://www.ncbi.nlm.nih.gov/pubmed/25324780
http://dx.doi.org/10.3389/fphys.2014.00370
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author Navarro, Gemma
Borroto-Escuela, Dasiel O.
Fuxe, Kjell
Franco, Rafael
author_facet Navarro, Gemma
Borroto-Escuela, Dasiel O.
Fuxe, Kjell
Franco, Rafael
author_sort Navarro, Gemma
collection PubMed
description Caveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with a hairpin-like structure. Caveolae participate in receptor-mediated trafficking of cell surface receptors and receptor-mediated signaling. Furthermore, caveolae participate in clathrin-independent endocytosis of membrane receptors. On the one hand, caveolins are involved in vascular and cardiac dysfunction. Also, neurological abnormalities in caveolin-1 knockout mice and a link between caveolin-1 gene haplotypes and neurodegenerative diseases have been reported. The aim of this article is to present the rationale for considering caveolae as potential targets in cardiovascular and neurological diseases.
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spelling pubmed-41796882014-10-16 Potential of caveolae in the therapy of cardiovascular and neurological diseases Navarro, Gemma Borroto-Escuela, Dasiel O. Fuxe, Kjell Franco, Rafael Front Physiol Physiology Caveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with a hairpin-like structure. Caveolae participate in receptor-mediated trafficking of cell surface receptors and receptor-mediated signaling. Furthermore, caveolae participate in clathrin-independent endocytosis of membrane receptors. On the one hand, caveolins are involved in vascular and cardiac dysfunction. Also, neurological abnormalities in caveolin-1 knockout mice and a link between caveolin-1 gene haplotypes and neurodegenerative diseases have been reported. The aim of this article is to present the rationale for considering caveolae as potential targets in cardiovascular and neurological diseases. Frontiers Media S.A. 2014-09-30 /pmc/articles/PMC4179688/ /pubmed/25324780 http://dx.doi.org/10.3389/fphys.2014.00370 Text en Copyright © 2014 Navarro, Borroto-Escuela, Fuxe and Franco. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Navarro, Gemma
Borroto-Escuela, Dasiel O.
Fuxe, Kjell
Franco, Rafael
Potential of caveolae in the therapy of cardiovascular and neurological diseases
title Potential of caveolae in the therapy of cardiovascular and neurological diseases
title_full Potential of caveolae in the therapy of cardiovascular and neurological diseases
title_fullStr Potential of caveolae in the therapy of cardiovascular and neurological diseases
title_full_unstemmed Potential of caveolae in the therapy of cardiovascular and neurological diseases
title_short Potential of caveolae in the therapy of cardiovascular and neurological diseases
title_sort potential of caveolae in the therapy of cardiovascular and neurological diseases
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179688/
https://www.ncbi.nlm.nih.gov/pubmed/25324780
http://dx.doi.org/10.3389/fphys.2014.00370
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