Activated Notch Causes Deafness by Promoting a Supporting Cell Phenotype in Developing Auditory Hair Cells

PURPOSE: To determine whether activated Notch can promote a supporting cell fate during sensory cell differentiation in the inner ear. METHODS: An activated form of the Notch1 receptor (NICD) was expressed in early differentiating hair cells using a Gfi1-Cre mouse allele. To determine the effects of...

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Detalles Bibliográficos
Autores principales: Savoy-Burke, Grace, Gilels, Felicia A., Pan, Wei, Pratt, Diana, Que, Jianwen, Gan, Lin, White, Patricia M., Kiernan, Amy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180070/
https://www.ncbi.nlm.nih.gov/pubmed/25264928
http://dx.doi.org/10.1371/journal.pone.0108160

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