Cargando…

The neutralizing function of the anti-HTLV-1 antibody is essential in preventing in vivo transmission of HTLV-1 to human T cells in NOD-SCID/γcnull (NOG) mice

BACKGROUND: Human T-cell leukemia virus type 1 (HTLV-1) causes both neoplastic and inflammatory diseases, including adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Because these life-threatening and disabling diseases are not yet curable, it is importan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saito, Mineki, Tanaka, Reiko, Fujii, Hideki, Kodama, Akira, Takahashi, Yoshiaki, Matsuzaki, Toshio, Takashima, Hiroshi, Tanaka, Yuetsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180130/ https://www.ncbi.nlm.nih.gov/pubmed/25163482 http://dx.doi.org/10.1186/s12977-014-0074-z

Ejemplares similares

Complete prevention of HTLV-1 infection in humanized mice (hu-PBL SCID) by a neutralizing monoclonal antibody to envelope gp46
por: Saito, Mineki, et al.
Publicado: (2014)

Neutralizing antibodies against human T cell leukemia virus type-I (HTLV-1) eradicate HTLV-1 in combination with autologous peripheral blood mononuclear cells via antibody-dependent cellular cytotoxicity while preventing new infection
por: Tanaka, Yuetsu, et al.
Publicado: (2014)

Absolute quantification of HTLV-1 basic leucine zipper factor (HBZ) protein and its plasma antibody in HTLV-1 infected individuals with different clinical status
por: Shiohama, Yasuo, et al.
Publicado: (2016)

Successful development of novel monoclonal antibodies against HTLV-1 bZIP factor and their applications in studying the pathogenesis of HAM/TSP
por: Saito, Mineki, et al.
Publicado: (2011)

Prevalence of plasma autoantibody against cancer testis antigen NY-ESO-1 in HTLV-1 infected individuals with different clinical status
por: Shiohama, Yasuo, et al.
Publicado: (2017)

Increased expression of OX40 is associated with progressive disease in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis
por: Saito, Mineki, et al.
Publicado: (2013)

Generation of direct antigen-sandwich enzyme-linked immune-sorbent assays (ELISA) for quantitation of HTLV-1 gp46, p24, Tax and related host cellular antigens OX40, OX40L and CD25
por: Tanaka, Reiko, et al.
Publicado: (2014)

Reduced Tim-3 expression on HTLV-I Tax-specific cytotoxic T lymphocytes in HTLV-I infection
por: Abdelbary, Nashwa H, et al.
Publicado: (2011)

Inhibition of ABL1 tyrosine kinase reduces HTLV-1 proviral loads in peripheral blood mononuclear cells from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis
por: Kodama, Daisuke, et al.
Publicado: (2020)

Conservation of a Neutralization Epitope of Human T-cell Leukemia Virus Type 1 (HTLV-1) among Currently Endemic Clinical Isolates in Okinawa, Japan
por: Mizuguchi, Mariko, et al.
Publicado: (2020)

EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV-1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV-1-infected individuals, irrespective of clinical statuses
por: Naito, Tadasuke, et al.
Publicado: (2019)

Heat Shock Enhances the Expression of the Human T Cell Leukemia Virus Type-I (HTLV-I) Trans-Activator (Tax) Antigen in Human HTLV-I Infected Primary and Cultured T Cells
por: Kunihiro, Marie, et al.
Publicado: (2016)

The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis
por: Saito, Mineki, et al.
Publicado: (2017)

The Preconditioning of Busulfan Promotes Efficiency of Human CD133+ Cells Engraftment in NOD Shi-SCID IL2Rγcnull (NOG) Mice via Intra-Bone Marrow Injection
por: Guo, Xiaofang, et al.
Publicado: (2019)

Visualization of HTLV-1–Specific Cytotoxic T Lymphocytes in the Spinal Cords of Patients With HTLV-1–Associated Myelopathy/Tropical Spastic Paraparesis
por: Matsuura, Eiji, et al.
Publicado: (2015)

Anti-Human T-Cell Leukemia Virus Type 1 (HTLV-1) Antibody Assays in Cerebrospinal Fluid for the Diagnosis of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis
por: Kodama, Daisuke, et al.
Publicado: (2021)

Early diagnosis of HTLV-1-associated myelopathy (HAM/TSP) in HTLV-1 carrier clinic
por: Matsuzaki, Toshio, et al.
Publicado: (2014)

Carrier model of HTLV-1 infection in humanized NOG mice
por: Tezuka, Kenta, et al.
Publicado: (2014)

Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis
por: Nozuma, Satoshi, et al.
Publicado: (2017)

A Potential of an Anti-HTLV-I gp46 Neutralizing Monoclonal Antibody (LAT-27) for Passive Immunization against Both Horizontal and Mother-to-Child Vertical Infection with Human T Cell Leukemia Virus Type-I
por: Fujii, Hideki, et al.
Publicado: (2016)

Molecular and clinical analyses of HTLV-1 subgroups associated with the risk of developing HAM/TSP.
por: Saito, Mineki, et al.
Publicado: (2015)

Control of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Eliminating Envelope Protein-Positive Cells with Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor
por: Tezuka, Kenta, et al.
Publicado: (2018)

A novel and simple method for generation of human dendritic cells from unfractionated peripheral blood mononuclear cells within 2 days: its application for induction of HIV-1-reactive CD4(+) T cells in the hu-PBL SCID mice
por: Kodama, Akira, et al.
Publicado: (2013)

Altered pattern in viral mRNA expression of Iranian type HTLV-1 leading to enhanced viral expression
por: Ueno, Takaharu, et al.
Publicado: (2014)

SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR
por: Kamoi, Koju, et al.
Publicado: (2006)

Inflammation with HTLV-1-specific CTLs occurs in the spinal cord of HTLV-1 carriers and the brain of the patients with HAM/TSP
por: Matsuura, Eiji, et al.
Publicado: (2014)

In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
por: Saito, Mineki, et al.
Publicado: (2009)

A protective role of HTLV-1 gp46-specific neutralizing and antibody-dependent cellular cytotoxicity-inducing antibodies in progression to adult T-cell leukemia (ATL)
por: Tanaka, Yuetsu, et al.
Publicado: (2022)

High frequency of CD4(+)FoxP3(+) cells in HTLV-1 infection: inverse correlation with HTLV-1–specific CTL response
por: Toulza, Frederic, et al.
Publicado: (2008)

Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2
por: Shoji, Toshiyuki, et al.
Publicado: (2009)

Identification and tracking of HTLV-1–infected T cell clones in virus-associated neurologic disease
por: Nozuma, Satoshi, et al.
Publicado: (2023)

Association Between HTLV-1 Genotypes and Risk of HAM/TSP
por: Saito, Mineki
Publicado: (2019)

Dynamics and consequences of the HTLV-1 proviral plus-strand burst
por: Ramanayake, Saumya, et al.
Publicado: (2022)

HTLV-1 infected CD4+T cells of HAM/TSP patients are susceptible to tunicamycin-induced endoplasmic reticulum stress
por: Kodama, Daisuke, et al.
Publicado: (2015)

HTLV-1 Infection and Its Associated Diseases
por: Saito, Mineki, et al.
Publicado: (2012)

The plasticity of HTLV-1 infected CD4+CD25+CCR4+ T-cells through HTLV-1 tax in HAM/TSP
por: Araya, Natsumi, et al.
Publicado: (2011)

Opportunistic Infections in Patients with HTLV-1 Infection
por: Tanaka, Toshiki, et al.
Publicado: (2015)

Distinct gene expression signatures induced by viral transactivators of different HTLV-1 subgroups that confer a different risk of HAM/TSP
por: Naito, Tadasuke, et al.
Publicado: (2018)

Efficacy of l‐Arginine treatment in patients with HTLV‐1‐associated neurological disease
por: Nozuma, Satoshi, et al.
Publicado: (2022)

ATL-like overgrowth and clonal expansion of HTLV-1 infected CD25+ CD4+ T- lymphocyte in humanized-NOG mouse model
por: Fujisawa, Jun-ichi, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_c5nhtvjkup00a7ttfc1eafj6ht