Pharmacologic Inhibition of MLK3 Kinase Activity Blocks the In Vitro Migratory Capacity of Breast Cancer Cells but Has No Effect on Breast Cancer Brain Metastasis in a Mouse Xenograft Model

Brain metastasis of breast cancer is an important clinical problem, with few therapeutic options and a poor prognosis. Recent data have implicated mixed lineage kinase 3 (MLK3) in controlling the in vitro migratory capacity of breast cancer cells, as well as the metastasis of MDA-MB-231 breast cance...

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Detalles Bibliográficos
Autores principales: Rhoo, Kun Hyoe, Granger, Megan, Sur, Joynita, Feng, Changyong, Gelbard, Harris A., Dewhurst, Stephen, Polesskaya, Oksana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180451/
https://www.ncbi.nlm.nih.gov/pubmed/25264786
http://dx.doi.org/10.1371/journal.pone.0108487

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