Cargando…

Ahnak functions as a tumor suppressor via modulation of TGFβ/Smad signaling pathway

We provide detailed mechanisms of Ahnak-mediated potentiation of transforming growth factor β (TGFβ) signaling, which leads to a negative regulation of cell growth. We show that Smad3 interacts with Ahnak through MH2 domain and that Ahnak stimulates Smad3 localization into nucleus leading to potenti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, I H, Sohn, M, Lim, H J, Yoon, S, Oh, H, Shin, S, Shin, J H, Oh, S-H, Kim, J, Lee, D K, Noh, D Y, Bae, D S, Seong, J K, Bae, Y S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180639/ https://www.ncbi.nlm.nih.gov/pubmed/24662814 http://dx.doi.org/10.1038/onc.2014.69

Ejemplares similares

Ahnak depletion accelerates liver regeneration by modulating the TGF-β/Smad signaling pathway
por: Yang, Insook, et al.
Publicado: (2022)

Ahnak promotes tumor metastasis through transforming growth factor-β-mediated epithelial-mesenchymal transition
por: Sohn, Mira, et al.
Publicado: (2018)

AHNAK deficiency promotes browning and lipolysis in mice via increased responsiveness to β-adrenergic signalling
por: Shin, Jae Hoon, et al.
Publicado: (2016)

Ahnak is required to balance calcium ion homeostasis and smooth muscle development in the urinary system
por: Lee, Jong-Min, et al.
Publicado: (2023)

AHNAK2 Promotes Migration, Invasion, and Epithelial-Mesenchymal Transition in Lung Adenocarcinoma Cells via the TGF-β/Smad3 Pathway
por: Liu, Gang, et al.
Publicado: (2020)

Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma
por: Peng, Rui, et al.
Publicado: (2019)

KLF17 empowers TGF-β/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression
por: Ali, A, et al.
Publicado: (2015)

DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-β/SMAD4 signaling
por: Chan, D W, et al.
Publicado: (2017)

Corni Fructus Alleviates UUO-Induced Renal Fibrosis via TGF-β/Smad Signaling
por: Lee, Jin A., et al.
Publicado: (2022)

Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction
por: Kim, Yo Na, et al.
Publicado: (2021)

Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak (-/-) Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure
por: Shin, Jae Hoon, et al.
Publicado: (2015)

Catechin hydrate ameliorates cerulein‑induced chronic pancreatitis via the inactivation of TGF‑β/Smad2 signaling
por: Kweon, Bitna, et al.
Publicado: (2023)

Correction: Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak (-/-) Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure
por: Shin, Jae Hoon, et al.
Publicado: (2015)

Transforming Growth Factor Beta (TGF-β) Is a Muscle Biomarker of Disease Progression in ALS and Correlates with Smad Expression
por: Si, Ying, et al.
Publicado: (2015)

Rejuvenation by inhibiting TGF-β1/pSmad signaling
por: Corder, Elizabeth H., et al.
Publicado: (2015)

PGC-1α Suppresses the Activation of TGF-β/Smad Signaling via Targeting TGFβRI Downregulation by let-7b/c Upregulation
por: Choi, Hoon-In, et al.
Publicado: (2019)

The Obscure Potential of AHNAK2
por: Zardab, Mohamed, et al.
Publicado: (2022)

Relationship between ETS Transcription Factor ETV1 and TGF-β-regulated SMAD Proteins in Prostate Cancer
por: Oh, Sangphil, et al.
Publicado: (2019)

TrkB-Induced Inhibition of R-SMAD/SMAD4 Activation is Essential for TGF-β-Mediated Tumor Suppressor Activity
por: Kim, Min Soo, et al.
Publicado: (2020)

TGF-β/Smad Signalling in Neurogenesis: Implications for Neuropsychiatric Diseases
por: Hiew, Lih-Fhung, et al.
Publicado: (2021)

Essential role of Ahnak in adipocyte differentiation leading to the transcriptional regulation of Bmpr1α expression
por: Woo, Jong Kyu, et al.
Publicado: (2018)

Novel tumor suppressive function of Smad4 in serum starvation-induced cell death through PAK1–PUMA pathway
por: Lee, S-H, et al.
Publicado: (2011)

AHNAKs roles in physiology and malignant tumors
por: Zhang, Shusen, et al.
Publicado: (2023)

Overexpression of SMC4 activates TGFβ/Smad signaling and promotes aggressive phenotype in glioma cells
por: Jiang, L, et al.
Publicado: (2017)

Piperine ameliorates the severity of fibrosis via inhibition of TGF-β/SMAD signaling in a mouse model of chronic pancreatitis
por: Choi, Ji-Won, et al.
Publicado: (2019)

AHNAK2 is a biomarker and a potential therapeutic target of adenocarcinomas: AHNAK2 is a biomarker for adenocarcinomas
por: Xu, Meng, et al.
Publicado: (2022)

Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome
por: Tufegdzic Vidakovic, Ana, et al.
Publicado: (2015)

Correction: Overexpression of SMC4 activates TGFβ/Smad signaling and promotes aggressive phenotype in glioma cells
por: Jiang, L., et al.
Publicado: (2022)

DBC2/RhoBTB2 functions as a tumor suppressor protein via Musashi-2 ubiquitination in breast cancer
por: Choi, Y M, et al.
Publicado: (2017)

Ahnak-knockout mice show susceptibility to Bartonella henselae infection because of CD4+ T cell inactivation and decreased cytokine secretion
por: Choi, Eun Wha, et al.
Publicado: (2019)

ShcA Protects against Epithelial–Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation
por: Muthusamy, Baby Periyanayaki, et al.
Publicado: (2015)

Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells
por: Suh, Jung Min, et al.
Publicado: (2021)

Scaffold protein FHL2 facilitates MDM2-mediated degradation of IER3 to regulate proliferation of cervical cancer cells
por: Jin, H, et al.
Publicado: (2016)

TGF-β/Smad signaling in renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2015)

The causative organisms of bacterial meningitis in Korean children, 1986-1995.
por: Kim, K. H., et al.
Publicado: (1998)

Msk is required for nuclear import of TGF-β/BMP-activated Smads
por: Xu, Lan, et al.
Publicado: (2007)

Targeting Stat3 and Smad7 to restore TGF-β cytostatic regulation of tumor cells in vitro and in vivo
por: Luwor, R B, et al.
Publicado: (2013)

Nuclear Respiratory Factor-1, a Novel SMAD4 Binding Protein, Represses TGF-β/SMAD4 Signaling by Functioning as a Transcriptional Cofactor
por: Rajasekaran, Nirmal, et al.
Publicado: (2021)

Downregulation of CR6-interacting factor 1 suppresses keloid fibroblast growth via the TGF-β/Smad signaling pathway
por: Nagar, Harsha, et al.
Publicado: (2021)

MiR-29b controls fetal mouse neurogenesis by regulating ICAT-mediated Wnt/β-catenin signaling
por: Shin, J, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_s8o101b42ea62l9ckjn24j5n36