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Maternal Methylenetetrahydrofolate Reductase C677T Polymorphism and Down Syndrome Risk: A Meta-Analysis from 34 Studies

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate metabolic pathway which catalyzes the irreversible conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate donates methyl group for the methylation of homocysteine to methion...

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Detalles Bibliográficos
Autores principales:	Rai, Vandana, Yadav, Upendra, Kumar, Pradeep, Yadav, Sushil Kumar, Mishra, Om Prakesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180743/ https://www.ncbi.nlm.nih.gov/pubmed/25265565 http://dx.doi.org/10.1371/journal.pone.0108552

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