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Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A
The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify g...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180879/ https://www.ncbi.nlm.nih.gov/pubmed/25105248 http://dx.doi.org/10.1038/ncomms5613 |
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| author | Wang, Hansong Burnett, Terrilea Kono, Suminori Haiman, Christopher A. Iwasaki, Motoki Wilkens, Lynne R. Loo, Lenora W.M. Berg, David Van Den Kolonel, Laurence N. Henderson, Brian E. Keku, Temitope O. Sandler, Robert S. Signorello, Lisa B. Blot, William J. Newcomb, Polly A. Pande, Mala Amos, Christopher I. West, Dee W. Bézieau, Stéphane Berndt, Sonja I. Zanke, Brent W. Hsu, Li Lindor, Noralane M. Haile, Robert W. Hopper, John L. Jenkins, Mark A. Gallinger, Steven Casey, Graham Stenzel, Stephanie L. Schumacher, Fredrick R. Peters, Ulrike Gruber, Stephen B. Tsugane, Shoichiro Stram, Daniel O. Marchand, Loïc Le |
| author_facet | Wang, Hansong Burnett, Terrilea Kono, Suminori Haiman, Christopher A. Iwasaki, Motoki Wilkens, Lynne R. Loo, Lenora W.M. Berg, David Van Den Kolonel, Laurence N. Henderson, Brian E. Keku, Temitope O. Sandler, Robert S. Signorello, Lisa B. Blot, William J. Newcomb, Polly A. Pande, Mala Amos, Christopher I. West, Dee W. Bézieau, Stéphane Berndt, Sonja I. Zanke, Brent W. Hsu, Li Lindor, Noralane M. Haile, Robert W. Hopper, John L. Jenkins, Mark A. Gallinger, Steven Casey, Graham Stenzel, Stephanie L. Schumacher, Fredrick R. Peters, Ulrike Gruber, Stephen B. Tsugane, Shoichiro Stram, Daniel O. Marchand, Loïc Le |
| author_sort | Wang, Hansong |
| collection | PubMed |
| description | The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P < 5×10(−8)) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.4×10(−9)), providing additional insight into the etiology of CRC and highlighting the value of association mapping in diverse populations. |
| format | Online Article Text |
| id | pubmed-4180879 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-41808792015-02-08 Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A Wang, Hansong Burnett, Terrilea Kono, Suminori Haiman, Christopher A. Iwasaki, Motoki Wilkens, Lynne R. Loo, Lenora W.M. Berg, David Van Den Kolonel, Laurence N. Henderson, Brian E. Keku, Temitope O. Sandler, Robert S. Signorello, Lisa B. Blot, William J. Newcomb, Polly A. Pande, Mala Amos, Christopher I. West, Dee W. Bézieau, Stéphane Berndt, Sonja I. Zanke, Brent W. Hsu, Li Lindor, Noralane M. Haile, Robert W. Hopper, John L. Jenkins, Mark A. Gallinger, Steven Casey, Graham Stenzel, Stephanie L. Schumacher, Fredrick R. Peters, Ulrike Gruber, Stephen B. Tsugane, Shoichiro Stram, Daniel O. Marchand, Loïc Le Nat Commun Article The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P < 5×10(−8)) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.4×10(−9)), providing additional insight into the etiology of CRC and highlighting the value of association mapping in diverse populations. 2014-08-08 /pmc/articles/PMC4180879/ /pubmed/25105248 http://dx.doi.org/10.1038/ncomms5613 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Wang, Hansong Burnett, Terrilea Kono, Suminori Haiman, Christopher A. Iwasaki, Motoki Wilkens, Lynne R. Loo, Lenora W.M. Berg, David Van Den Kolonel, Laurence N. Henderson, Brian E. Keku, Temitope O. Sandler, Robert S. Signorello, Lisa B. Blot, William J. Newcomb, Polly A. Pande, Mala Amos, Christopher I. West, Dee W. Bézieau, Stéphane Berndt, Sonja I. Zanke, Brent W. Hsu, Li Lindor, Noralane M. Haile, Robert W. Hopper, John L. Jenkins, Mark A. Gallinger, Steven Casey, Graham Stenzel, Stephanie L. Schumacher, Fredrick R. Peters, Ulrike Gruber, Stephen B. Tsugane, Shoichiro Stram, Daniel O. Marchand, Loïc Le Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A |
| title | Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A |
| title_full | Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A |
| title_fullStr | Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A |
| title_full_unstemmed | Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A |
| title_short | Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A |
| title_sort | trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in vti1a |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180879/ https://www.ncbi.nlm.nih.gov/pubmed/25105248 http://dx.doi.org/10.1038/ncomms5613 |
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