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Stable malaria incidence despite scaling up control strategies in a malaria vaccine-testing site in Mali

BACKGROUND: The recent decline in malaria incidence in many African countries has been attributed to the provision of prompt and effective anti-malarial treatment using artemisinin-based combination therapy (ACT) and to the widespread distribution of long-lasting, insecticide-treated bed nets (LLINs...

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Autores principales: Coulibaly, Drissa, Travassos, Mark A, Kone, Abdoulaye K, Tolo, Youssouf, Laurens, Matthew B, Traore, Karim, Diarra, Issa, Niangaly, Amadou, Daou, Modibo, Dembele, Ahmadou, Sissoko, Mody, Guindo, Bouréima, Douyon, Raymond, Guindo, Aldiouma, Kouriba, Bourema, Sissoko, Mahamadou S, Sagara, Issaka, Plowe, Christopher V, Doumbo, Ogobara K, Thera, Mahamadou A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180968/
https://www.ncbi.nlm.nih.gov/pubmed/25238721
http://dx.doi.org/10.1186/1475-2875-13-374
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author Coulibaly, Drissa
Travassos, Mark A
Kone, Abdoulaye K
Tolo, Youssouf
Laurens, Matthew B
Traore, Karim
Diarra, Issa
Niangaly, Amadou
Daou, Modibo
Dembele, Ahmadou
Sissoko, Mody
Guindo, Bouréima
Douyon, Raymond
Guindo, Aldiouma
Kouriba, Bourema
Sissoko, Mahamadou S
Sagara, Issaka
Plowe, Christopher V
Doumbo, Ogobara K
Thera, Mahamadou A
author_facet Coulibaly, Drissa
Travassos, Mark A
Kone, Abdoulaye K
Tolo, Youssouf
Laurens, Matthew B
Traore, Karim
Diarra, Issa
Niangaly, Amadou
Daou, Modibo
Dembele, Ahmadou
Sissoko, Mody
Guindo, Bouréima
Douyon, Raymond
Guindo, Aldiouma
Kouriba, Bourema
Sissoko, Mahamadou S
Sagara, Issaka
Plowe, Christopher V
Doumbo, Ogobara K
Thera, Mahamadou A
author_sort Coulibaly, Drissa
collection PubMed
description BACKGROUND: The recent decline in malaria incidence in many African countries has been attributed to the provision of prompt and effective anti-malarial treatment using artemisinin-based combination therapy (ACT) and to the widespread distribution of long-lasting, insecticide-treated bed nets (LLINs). At a malaria vaccine-testing site in Bandiagara, Mali, ACT was introduced in 2004, and LLINs have been distributed free of charge since 2007 to infants after they complete the Expanded Programme of Immunization (EPI) schedule and to pregnant women receiving antenatal care. These strategies may have an impact on malaria incidence. METHODS: To document malaria incidence, a cohort of 400 children aged 0 to 14 years was followed for three to four years up to July 2013. Monthly cross-sectional surveys were done to measure the prevalence of malaria infection and anaemia. Clinical disease was measured both actively and passively through continuous availability of primary medical care. Measured outcomes included asymptomatic Plasmodium infection, anaemia and clinical malaria episodes. RESULTS: The incidence rate of clinical malaria varied significantly from June 2009 to July 2013 without a clear downward trend. A sharp seasonality in malaria illness incidence was observed with higher clinical malaria incidence rates during the rainy season. Parasite and anaemia point prevalence also showed seasonal variation with much higher prevalence rates during rainy seasons compared to dry seasons. CONCLUSIONS: Despite the scaling up of malaria prevention and treatment, including the widespread use of bed nets, better diagnosis and wider availability of ACT, malaria incidence did not decrease in Bandiagara during the study period.
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spelling pubmed-41809682014-10-03 Stable malaria incidence despite scaling up control strategies in a malaria vaccine-testing site in Mali Coulibaly, Drissa Travassos, Mark A Kone, Abdoulaye K Tolo, Youssouf Laurens, Matthew B Traore, Karim Diarra, Issa Niangaly, Amadou Daou, Modibo Dembele, Ahmadou Sissoko, Mody Guindo, Bouréima Douyon, Raymond Guindo, Aldiouma Kouriba, Bourema Sissoko, Mahamadou S Sagara, Issaka Plowe, Christopher V Doumbo, Ogobara K Thera, Mahamadou A Malar J Research BACKGROUND: The recent decline in malaria incidence in many African countries has been attributed to the provision of prompt and effective anti-malarial treatment using artemisinin-based combination therapy (ACT) and to the widespread distribution of long-lasting, insecticide-treated bed nets (LLINs). At a malaria vaccine-testing site in Bandiagara, Mali, ACT was introduced in 2004, and LLINs have been distributed free of charge since 2007 to infants after they complete the Expanded Programme of Immunization (EPI) schedule and to pregnant women receiving antenatal care. These strategies may have an impact on malaria incidence. METHODS: To document malaria incidence, a cohort of 400 children aged 0 to 14 years was followed for three to four years up to July 2013. Monthly cross-sectional surveys were done to measure the prevalence of malaria infection and anaemia. Clinical disease was measured both actively and passively through continuous availability of primary medical care. Measured outcomes included asymptomatic Plasmodium infection, anaemia and clinical malaria episodes. RESULTS: The incidence rate of clinical malaria varied significantly from June 2009 to July 2013 without a clear downward trend. A sharp seasonality in malaria illness incidence was observed with higher clinical malaria incidence rates during the rainy season. Parasite and anaemia point prevalence also showed seasonal variation with much higher prevalence rates during rainy seasons compared to dry seasons. CONCLUSIONS: Despite the scaling up of malaria prevention and treatment, including the widespread use of bed nets, better diagnosis and wider availability of ACT, malaria incidence did not decrease in Bandiagara during the study period. BioMed Central 2014-09-19 /pmc/articles/PMC4180968/ /pubmed/25238721 http://dx.doi.org/10.1186/1475-2875-13-374 Text en © Coulibaly et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Coulibaly, Drissa
Travassos, Mark A
Kone, Abdoulaye K
Tolo, Youssouf
Laurens, Matthew B
Traore, Karim
Diarra, Issa
Niangaly, Amadou
Daou, Modibo
Dembele, Ahmadou
Sissoko, Mody
Guindo, Bouréima
Douyon, Raymond
Guindo, Aldiouma
Kouriba, Bourema
Sissoko, Mahamadou S
Sagara, Issaka
Plowe, Christopher V
Doumbo, Ogobara K
Thera, Mahamadou A
Stable malaria incidence despite scaling up control strategies in a malaria vaccine-testing site in Mali
title Stable malaria incidence despite scaling up control strategies in a malaria vaccine-testing site in Mali
title_full Stable malaria incidence despite scaling up control strategies in a malaria vaccine-testing site in Mali
title_fullStr Stable malaria incidence despite scaling up control strategies in a malaria vaccine-testing site in Mali
title_full_unstemmed Stable malaria incidence despite scaling up control strategies in a malaria vaccine-testing site in Mali
title_short Stable malaria incidence despite scaling up control strategies in a malaria vaccine-testing site in Mali
title_sort stable malaria incidence despite scaling up control strategies in a malaria vaccine-testing site in mali
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180968/
https://www.ncbi.nlm.nih.gov/pubmed/25238721
http://dx.doi.org/10.1186/1475-2875-13-374
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