Cargando…

Bioactive protein fraction DLBS1033 containing lumbrokinase isolated from Lumbricus rubellus: ex vivo, in vivo, and pharmaceutic studies

DLBS1033 is a bioactive protein fraction isolated from Lumbricus rubellus that tends to be unstable when exposed to the gastrointestinal environment. Accordingly, appropriate pharmaceutical development is needed to maximize absorption of the protein fraction in the gastrointestinal tract. In vitro,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tjandrawinata, Raymond R, Trisina, Jessica, Rahayu, Puji, Prasetya, Lorentius Agung, Hanafiah, Aang, Rachmawati, Heni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181543/ https://www.ncbi.nlm.nih.gov/pubmed/25284988 http://dx.doi.org/10.2147/DDDT.S66007

Ejemplares similares

DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic and Thrombolytic Activities
por: Trisina, Jessica, et al.
Publicado: (2011)

Purification and proteomic analysis of potent fibrinolytic enzymes extracted from Lumbricus rubellus
por: Stephani, Laurentia, et al.
Publicado: (2023)

Metallothionein gene activation in the earthworm (Lumbricus rubellus)
por: Höckner, M., et al.
Publicado: (2015)

Effect of DLBS1033 on Functional Outcomes for Patients with Acute Ischemic Stroke: A Randomized Controlled Trial
por: Pinzon, Rizaldy Taslim, et al.
Publicado: (2021)

Antibacterial Activity of Lumbricus Rubellus Earthworm Extract Against Porphyromonas Gingivalis as the Bacterial Cause of Periodontitis
por: Dharmawati, I Gusti Agung Ayu, et al.
Publicado: (2019)

Palatability of Selected Alpine Plant Litters for the Decomposer Lumbricus rubellus (Lumbricidae)
por: Rief, Alexander, et al.
Publicado: (2012)

Deeply divergent sympatric mitochondrial lineages of the earthworm Lumbricus rubellus are not reproductively isolated
por: Giska, Iwona, et al.
Publicado: (2015)

Genetic variation in populations of the earthworm, Lumbricus rubellus, across contaminated mine sites
por: Anderson, Craig, et al.
Publicado: (2017)

Data on the potent fibrinolytic effects of the Lumbricus rubellus earthworm and the Perinereis linea lugworm
por: Dong, Yuanyuan, et al.
Publicado: (2019)

The complete mitochondrial genome of Lumbricus rubellus (Oligochaeta, Lumbricidae) and its phylogenetic analysis
por: Zhang, Qingzheng, et al.
Publicado: (2019)

Potential Antiaging Effects of DLBS1649, a Centella asiatica Bioactive Extract
por: Karsono, Agung H, et al.
Publicado: (2021)

Transcriptome profiling of developmental and xenobiotic responses in a keystone soil animal, the oligochaete annelid Lumbricus rubellus
por: Owen, Jennifer, et al.
Publicado: (2008)

Earthworm Lumbricus rubellus MT-2: Metal Binding and Protein Folding of a True Cadmium-MT
por: Kowald, Gregory R., et al.
Publicado: (2016)

The Effects of Lumbricus rubellus Extract on Staphylococcus aureus Colonization and IL-31 Levels in Children with Atopic Dermatitis
por: Sara, Meutia, et al.
Publicado: (2023)

Bioactive fraction from Lagerstroemia speciosa leaves (DLBS3733) reduces fat droplet by inhibiting adipogenesis and lipogenesis
por: Karsono, Agung Heru, et al.
Publicado: (2019)

Molecular effects of bioactive fraction of Curcuma mangga (DLBS4847) as a downregulator of 5α-reductase activity pathways in prostatic epithelial cells
por: Karsono, Agung Heru, et al.
Publicado: (2014)

'Systems toxicology' approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellus
por: Bundy, Jacob G, et al.
Publicado: (2008)

Gastroprotective Effect of DLBS2411 Bioactive Fraction from Cinnamomum burmannii Against Ethanol-Induced Gastric Damage in Rats
por: Tjandrawinata, Raymond R, et al.
Publicado: (2020)

Symptomatic treatment of premenstrual syndrome and/or primary dysmenorrhea with DLBS1442, a bioactive extract of Phaleria macrocarpa
por: Tjandrawinata, Raymond R, et al.
Publicado: (2011)

Insulin sensitizer in prediabetes: a clinical study with DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa
por: Manaf, Asman, et al.
Publicado: (2016)

Antidiarrheal Effect of DLBS1Y62, a Bioactive Fraction of Uncaria gambir Roxb. Dried Sap Extract, in Wistar Rats
por: Wibowo, Dicky A, et al.
Publicado: (2021)

Coelomic Fluid of Lumbricus rubellus Synergistically Enhances Cytotoxic Effect of 5-Fluorouracil through Modulation of Focal Adhesion Kinase and p21 in HT-29 Cancer Cell Line
por: Endharti, Agustina Tri, et al.
Publicado: (2019)

The In Vitro–In Vivo Safety Confirmation of PEG-40 Hydrogenated Castor Oil as a Surfactant for Oral Nanoemulsion Formulation
por: Rachmawati, Heni, et al.
Publicado: (2017)

Glucose-lowering effect of DLBS3233 is mediated through phosphorylation of tyrosine and upregulation of PPARγ and GLUT4 expression
por: Tandrasasmita, Olivia Mayasari, et al.
Publicado: (2011)

In Silico Study to Develop a Lectin-Like Protein from Mushroom Agaricus bisporus for Pharmaceutical Application
por: Ismaya, Wangsa Tirta, et al.
Publicado: (2016)

Hydrogen potassium adenosine triphosphatase activity inhibition and downregulation of its expression by bioactive fraction DLBS2411 from Cinnamomum burmannii in gastric parietal cells
por: Tjandrawinata, Raymond R, et al.
Publicado: (2013)

Lectins from the Edible Mushroom Agaricus bisporus and Their Therapeutic Potentials
por: Tirta Ismaya, Wangsa, et al.
Publicado: (2020)

Tacorin, an extract from Ananas comosus stem, stimulates wound healing by modulating the expression of tumor necrosis factor α, transforming growth factor β and matrix metalloproteinase 2
por: Rahayu, Puji, et al.
Publicado: (2017)

The Effect and Safety Assessment of Metformin and DLBS3233 (A Bioactive Fraction of Lagerstroemia speciosa and Cinnamomum burmannii) on Improving Metabolic Parameters in Women with Polycystic Ovary Syndrome
por: Hidayat, Syarief Thaufik, et al.
Publicado: (2023)

Recombinant Protein Production of Earthworm Lumbrokinase for Potential Antithrombotic Application
por: Wang, Kevin Yueju, et al.
Publicado: (2013)

Ex Vivo Model to Evaluate the Antibacterial and Anti-Inflammatory Effects of Gelatin–Tricalcium Phosphate Composite Incorporated with Emodin and Lumbrokinase for Bone Regeneration
por: Wang, Wen-Ling, et al.
Publicado: (2023)

Lumbrokinase/paclitaxel nanoparticle complex: potential therapeutic applications in bladder cancer
por: Hu, Bo, et al.
Publicado: (2018)

Synthesis and evaluation of cationic polymeric micelles as carriers of lumbrokinase for targeted thrombolysis
por: Pan, Yang, et al.
Publicado: (2019)

Anti-inflammatory, antiangiogenic, and apoptosis-inducing activity of DLBS1442, a bioactive fraction of Phaleria macrocarpa, in a RL95-2 cell line as a molecular model of endometriosis
por: Tandrasasmita, Olivia M, et al.
Publicado: (2015)

CYTODIFFERENTIATION DURING SPERMIOGENESIS IN LUMBRICUS TERRESTRIS
por: Anderson, W. A., et al.
Publicado: (1967)

PReS13-SPK-1033: Neonatal lupus
por: Cimaz, R
Publicado: (2013)

Proteome analysis of shell matrix proteins in the brachiopod Laqueus rubellus
por: Isowa, Yukinobu, et al.
Publicado: (2015)

The thrombolytic effect of lumbrokinase is not as potent as urokinase in a rabbit cerebral embolism model.
por: Kim, J. S., et al.
Publicado: (1993)

Lumbrokinase effects on pro- and anti-apoptotic gene expression in Wistar rats with testicular torsion
por: Danarto, Raden, et al.
Publicado: (2019)

Spermiogenesis in Lumbricus herculeus : An Electron Microscope Study
por: Gatenby, J. Brontë, et al.
Publicado: (1959)

Cannot write session to /tmp/vufind_sessions/sess_erecs699d6jd49f0pu96rfog4s