Triple Negative Breast Cancer – An Overview

Triple Negative Breast Cancer (TNBC) is a heterogeneous disease that based on immunohistochemistry (IHC) is estrogen receptor (ER) negative, progesterone receptor (PR) negative and human epidermal growth factor receptor 2 (HER2) negative. TNBC is typically observed in young AA women and Hispanic wom...

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Autores principales: Aysola, Kartik, Desai, Akshata, Welch, Crystal, Xu, Jingyao, Qin, Yunlong, Reddy, Vaishali, Matthews, Roland, Owens, Charlotte, Okoli, Joel, Beech, Derrick J, Piyathilake, Chandrika J, Reddy, Shyam P, Rao, Veena N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181680/
https://www.ncbi.nlm.nih.gov/pubmed/25285241
http://dx.doi.org/10.4172/2161-1041.S2-001
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author Aysola, Kartik
Desai, Akshata
Welch, Crystal
Xu, Jingyao
Qin, Yunlong
Reddy, Vaishali
Matthews, Roland
Owens, Charlotte
Okoli, Joel
Beech, Derrick J
Piyathilake, Chandrika J
Reddy, Shyam P
Rao, Veena N
author_facet Aysola, Kartik
Desai, Akshata
Welch, Crystal
Xu, Jingyao
Qin, Yunlong
Reddy, Vaishali
Matthews, Roland
Owens, Charlotte
Okoli, Joel
Beech, Derrick J
Piyathilake, Chandrika J
Reddy, Shyam P
Rao, Veena N
author_sort Aysola, Kartik
collection PubMed
description Triple Negative Breast Cancer (TNBC) is a heterogeneous disease that based on immunohistochemistry (IHC) is estrogen receptor (ER) negative, progesterone receptor (PR) negative and human epidermal growth factor receptor 2 (HER2) negative. TNBC is typically observed in young AA women and Hispanic women who carry a mutation in the BRCA1 gene. TNBC is characterized by a distinct molecular profile, aggressive nature and lack of targeted therapies. The purpose of this article is to review the current and future novel signalling pathways as therapeutic approaches to TNBC. Recent Identification of a new BRCA1 trafficking pathway holds promise in the future for the development of targeted therapies for TNBC.
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spelling pubmed-41816802014-10-02 Triple Negative Breast Cancer – An Overview Aysola, Kartik Desai, Akshata Welch, Crystal Xu, Jingyao Qin, Yunlong Reddy, Vaishali Matthews, Roland Owens, Charlotte Okoli, Joel Beech, Derrick J Piyathilake, Chandrika J Reddy, Shyam P Rao, Veena N Hereditary Genet Article Triple Negative Breast Cancer (TNBC) is a heterogeneous disease that based on immunohistochemistry (IHC) is estrogen receptor (ER) negative, progesterone receptor (PR) negative and human epidermal growth factor receptor 2 (HER2) negative. TNBC is typically observed in young AA women and Hispanic women who carry a mutation in the BRCA1 gene. TNBC is characterized by a distinct molecular profile, aggressive nature and lack of targeted therapies. The purpose of this article is to review the current and future novel signalling pathways as therapeutic approaches to TNBC. Recent Identification of a new BRCA1 trafficking pathway holds promise in the future for the development of targeted therapies for TNBC. 2013 /pmc/articles/PMC4181680/ /pubmed/25285241 http://dx.doi.org/10.4172/2161-1041.S2-001 Text en © 2013 Aysola K, et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Aysola, Kartik
Desai, Akshata
Welch, Crystal
Xu, Jingyao
Qin, Yunlong
Reddy, Vaishali
Matthews, Roland
Owens, Charlotte
Okoli, Joel
Beech, Derrick J
Piyathilake, Chandrika J
Reddy, Shyam P
Rao, Veena N
Triple Negative Breast Cancer – An Overview
title Triple Negative Breast Cancer – An Overview
title_full Triple Negative Breast Cancer – An Overview
title_fullStr Triple Negative Breast Cancer – An Overview
title_full_unstemmed Triple Negative Breast Cancer – An Overview
title_short Triple Negative Breast Cancer – An Overview
title_sort triple negative breast cancer – an overview
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181680/
https://www.ncbi.nlm.nih.gov/pubmed/25285241
http://dx.doi.org/10.4172/2161-1041.S2-001
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