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Oxygen supersaturated fluid using fine micro/nanobubbles

Microbubbles show peculiar properties, such as shrinking collapse, long lifetime, high gas solubility, negative electric charge, and free radical production. Fluids supersaturated with various gases can be easily generated using microbubbles. Oxygen microbubble fluid can be very useful for oxygen de...

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Autores principales: Matsuki, Noriaki, Ishikawa, Takuji, Ichiba, Shingo, Shiba, Naoki, Ujike, Yoshihito, Yamaguchi, Takami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181745/
https://www.ncbi.nlm.nih.gov/pubmed/25285003
http://dx.doi.org/10.2147/IJN.S68840
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author Matsuki, Noriaki
Ishikawa, Takuji
Ichiba, Shingo
Shiba, Naoki
Ujike, Yoshihito
Yamaguchi, Takami
author_facet Matsuki, Noriaki
Ishikawa, Takuji
Ichiba, Shingo
Shiba, Naoki
Ujike, Yoshihito
Yamaguchi, Takami
author_sort Matsuki, Noriaki
collection PubMed
description Microbubbles show peculiar properties, such as shrinking collapse, long lifetime, high gas solubility, negative electric charge, and free radical production. Fluids supersaturated with various gases can be easily generated using microbubbles. Oxygen microbubble fluid can be very useful for oxygen delivery to hypoxic tissues. However, there have been no reports of comparative investigations into adding fluids containing oxygen fine micro/nanobubbles (OFM-NBs) to common infusion solutions in daily medical care. In this study, it was demonstrated that OFMNBs can generate oxygen-supersaturated fluids, and they may be sufficiently small to infuse safely into blood vessels. It was found that normal saline solution is preferable for generating an oxygen-rich infusion fluid, which is best administered as a 30-minute intravenous infusion. It was also concluded that dextran solution is suitable for drug delivery substances packing oxygen gas over a 1-hour intravenous infusion. In addition, normal saline solution containing OFMNBs was effective for improving blood oxygenation. Thus, the use of OFMNB-containing fluids is a potentially effective novel method for improving blood oxygenation in cases involving hypoxia, ischemic diseases, infection control, and anticancer chemoradiation therapies.
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spelling pubmed-41817452014-10-03 Oxygen supersaturated fluid using fine micro/nanobubbles Matsuki, Noriaki Ishikawa, Takuji Ichiba, Shingo Shiba, Naoki Ujike, Yoshihito Yamaguchi, Takami Int J Nanomedicine Original Research Microbubbles show peculiar properties, such as shrinking collapse, long lifetime, high gas solubility, negative electric charge, and free radical production. Fluids supersaturated with various gases can be easily generated using microbubbles. Oxygen microbubble fluid can be very useful for oxygen delivery to hypoxic tissues. However, there have been no reports of comparative investigations into adding fluids containing oxygen fine micro/nanobubbles (OFM-NBs) to common infusion solutions in daily medical care. In this study, it was demonstrated that OFMNBs can generate oxygen-supersaturated fluids, and they may be sufficiently small to infuse safely into blood vessels. It was found that normal saline solution is preferable for generating an oxygen-rich infusion fluid, which is best administered as a 30-minute intravenous infusion. It was also concluded that dextran solution is suitable for drug delivery substances packing oxygen gas over a 1-hour intravenous infusion. In addition, normal saline solution containing OFMNBs was effective for improving blood oxygenation. Thus, the use of OFMNB-containing fluids is a potentially effective novel method for improving blood oxygenation in cases involving hypoxia, ischemic diseases, infection control, and anticancer chemoradiation therapies. Dove Medical Press 2014-09-23 /pmc/articles/PMC4181745/ /pubmed/25285003 http://dx.doi.org/10.2147/IJN.S68840 Text en © 2014 Matsuki et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Matsuki, Noriaki
Ishikawa, Takuji
Ichiba, Shingo
Shiba, Naoki
Ujike, Yoshihito
Yamaguchi, Takami
Oxygen supersaturated fluid using fine micro/nanobubbles
title Oxygen supersaturated fluid using fine micro/nanobubbles
title_full Oxygen supersaturated fluid using fine micro/nanobubbles
title_fullStr Oxygen supersaturated fluid using fine micro/nanobubbles
title_full_unstemmed Oxygen supersaturated fluid using fine micro/nanobubbles
title_short Oxygen supersaturated fluid using fine micro/nanobubbles
title_sort oxygen supersaturated fluid using fine micro/nanobubbles
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181745/
https://www.ncbi.nlm.nih.gov/pubmed/25285003
http://dx.doi.org/10.2147/IJN.S68840
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