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Genetic diversity and molecular epidemiology of human rhinoviruses in South Africa

BACKGROUND: Rhinoviruses (RV) are a well-established cause of respiratory illness. RV-C has been associated with more severe illness. We aimed to characterize and compare the clinical presentations and disease severity of different RV type circulating in South Africa. METHOD: We performed two analys...

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Autores principales: Pretorius, Marthi A, Tempia, Stefano, Treurnicht, Florette K, Walaza, Sibongile, Cohen, Adam L, Moyes, Jocelyn, Hellferscee, Orienka, Variava, Ebrahim, Dawood, Halima, Chhagan, Meera, Haffjee, Sumayya, Madhi, Shabir A, Cohen, Cheryl, Venter, Marietjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181821/
https://www.ncbi.nlm.nih.gov/pubmed/24990601
http://dx.doi.org/10.1111/irv.12264
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author Pretorius, Marthi A
Tempia, Stefano
Treurnicht, Florette K
Walaza, Sibongile
Cohen, Adam L
Moyes, Jocelyn
Hellferscee, Orienka
Variava, Ebrahim
Dawood, Halima
Chhagan, Meera
Haffjee, Sumayya
Madhi, Shabir A
Cohen, Cheryl
Venter, Marietjie
author_facet Pretorius, Marthi A
Tempia, Stefano
Treurnicht, Florette K
Walaza, Sibongile
Cohen, Adam L
Moyes, Jocelyn
Hellferscee, Orienka
Variava, Ebrahim
Dawood, Halima
Chhagan, Meera
Haffjee, Sumayya
Madhi, Shabir A
Cohen, Cheryl
Venter, Marietjie
author_sort Pretorius, Marthi A
collection PubMed
description BACKGROUND: Rhinoviruses (RV) are a well-established cause of respiratory illness. RV-C has been associated with more severe illness. We aimed to characterize and compare the clinical presentations and disease severity of different RV type circulating in South Africa. METHOD: We performed two analyses of RV-positive specimens identified through surveillance in South Africa across all age groups. First, RV-positive specimens identified through severe acute respiratory illness (SARI) surveillance in four provinces was randomly selected from 2009 to 2010 for molecular characterization. Second, RV-positive specimens identified through SARI, influenza-like illness (ILI) and control surveillance at hospitals and outpatient clinics in during 2012–2013 were used to determine the association of RV type with severe disease. Selected specimens were sequenced, and phylogenetic analysis was performed. RESULTS: Among the 599 sequenced specimens from 2009 to 2010 and 2012 to 2013, RV-A (285, 48%) and RV-C (247, 41%) were more commonly identified than RV-B (67, 11%), with no seasonality and a high genetic diversity. A higher prevalence of RV infection was identified in cases with SARI [515/962 (26%); aRRR = 1·6; 95% CI 1·21; 2·2] and ILI [356/962 (28%); aRRR = 1·9; 95% CI 1·37; 2·6] compared with asymptomatic controls (91/962, 22%). There was no difference in disease severity between the different type when comparing SARI, ILI and controls. CONCLUSION: All three type of RV were identified in South Africa, although RV-A and RV-C were more common than RV-B. RV was associated with symptomatic respiratory illness; however, there was no association between RV type and disease severity.
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spelling pubmed-41818212014-10-29 Genetic diversity and molecular epidemiology of human rhinoviruses in South Africa Pretorius, Marthi A Tempia, Stefano Treurnicht, Florette K Walaza, Sibongile Cohen, Adam L Moyes, Jocelyn Hellferscee, Orienka Variava, Ebrahim Dawood, Halima Chhagan, Meera Haffjee, Sumayya Madhi, Shabir A Cohen, Cheryl Venter, Marietjie Influenza Other Respir Viruses Original Articles BACKGROUND: Rhinoviruses (RV) are a well-established cause of respiratory illness. RV-C has been associated with more severe illness. We aimed to characterize and compare the clinical presentations and disease severity of different RV type circulating in South Africa. METHOD: We performed two analyses of RV-positive specimens identified through surveillance in South Africa across all age groups. First, RV-positive specimens identified through severe acute respiratory illness (SARI) surveillance in four provinces was randomly selected from 2009 to 2010 for molecular characterization. Second, RV-positive specimens identified through SARI, influenza-like illness (ILI) and control surveillance at hospitals and outpatient clinics in during 2012–2013 were used to determine the association of RV type with severe disease. Selected specimens were sequenced, and phylogenetic analysis was performed. RESULTS: Among the 599 sequenced specimens from 2009 to 2010 and 2012 to 2013, RV-A (285, 48%) and RV-C (247, 41%) were more commonly identified than RV-B (67, 11%), with no seasonality and a high genetic diversity. A higher prevalence of RV infection was identified in cases with SARI [515/962 (26%); aRRR = 1·6; 95% CI 1·21; 2·2] and ILI [356/962 (28%); aRRR = 1·9; 95% CI 1·37; 2·6] compared with asymptomatic controls (91/962, 22%). There was no difference in disease severity between the different type when comparing SARI, ILI and controls. CONCLUSION: All three type of RV were identified in South Africa, although RV-A and RV-C were more common than RV-B. RV was associated with symptomatic respiratory illness; however, there was no association between RV type and disease severity. Blackwell Publishing Ltd 2014-09 2014-07-03 /pmc/articles/PMC4181821/ /pubmed/24990601 http://dx.doi.org/10.1111/irv.12264 Text en © 2014 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Pretorius, Marthi A
Tempia, Stefano
Treurnicht, Florette K
Walaza, Sibongile
Cohen, Adam L
Moyes, Jocelyn
Hellferscee, Orienka
Variava, Ebrahim
Dawood, Halima
Chhagan, Meera
Haffjee, Sumayya
Madhi, Shabir A
Cohen, Cheryl
Venter, Marietjie
Genetic diversity and molecular epidemiology of human rhinoviruses in South Africa
title Genetic diversity and molecular epidemiology of human rhinoviruses in South Africa
title_full Genetic diversity and molecular epidemiology of human rhinoviruses in South Africa
title_fullStr Genetic diversity and molecular epidemiology of human rhinoviruses in South Africa
title_full_unstemmed Genetic diversity and molecular epidemiology of human rhinoviruses in South Africa
title_short Genetic diversity and molecular epidemiology of human rhinoviruses in South Africa
title_sort genetic diversity and molecular epidemiology of human rhinoviruses in south africa
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181821/
https://www.ncbi.nlm.nih.gov/pubmed/24990601
http://dx.doi.org/10.1111/irv.12264
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