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EU-OPENSCREEN—chemical tools for the study of plant biology and resistance mechanisms
EU-OPENSCREEN is an academic research infrastructure initiative in Europe for enabling researchers in all life sciences to take advantage of chemical biology approaches to their projects. In a collaborative effort of national networks in 16 European countries, EU-OPENSCREEN will develop novel chemic...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182336/ https://www.ncbi.nlm.nih.gov/pubmed/25320643 http://dx.doi.org/10.1007/s12154-014-0118-9 |
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author | Meiners, Torsten Stechmann, Bahne Frank, Ronald |
author_facet | Meiners, Torsten Stechmann, Bahne Frank, Ronald |
author_sort | Meiners, Torsten |
collection | PubMed |
description | EU-OPENSCREEN is an academic research infrastructure initiative in Europe for enabling researchers in all life sciences to take advantage of chemical biology approaches to their projects. In a collaborative effort of national networks in 16 European countries, EU-OPENSCREEN will develop novel chemical compounds with external users to address questions in, among other fields, systems and network biology (directed and selective perturbation of signalling pathways), structural biology (compound-target interactions at atomic resolution), pharmacology (early drug discovery and toxicology) and plant biology (response of wild or crop plants to environmental and agricultural substances). EU-OPENSCREEN supports all stages of a tool development project, including assay adaptation, high-throughput screening and chemical optimisation of the ‘hit’ compounds. All tool compounds and data will be made available to the scientific community. EU-OPENSCREEN integrates high-capacity screening platforms throughout Europe, which share a rationally selected compound collection comprising up to 300,000 (commercial and proprietary compounds collected from European chemists). By testing systematically this chemical collection in hundreds of assays originating from very different biological themes, the screening process generates enormous amounts of information about the biological activities of the substances and thereby steadily enriches our understanding of how and where they act. |
format | Online Article Text |
id | pubmed-4182336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-41823362014-10-15 EU-OPENSCREEN—chemical tools for the study of plant biology and resistance mechanisms Meiners, Torsten Stechmann, Bahne Frank, Ronald J Chem Biol Notes EU-OPENSCREEN is an academic research infrastructure initiative in Europe for enabling researchers in all life sciences to take advantage of chemical biology approaches to their projects. In a collaborative effort of national networks in 16 European countries, EU-OPENSCREEN will develop novel chemical compounds with external users to address questions in, among other fields, systems and network biology (directed and selective perturbation of signalling pathways), structural biology (compound-target interactions at atomic resolution), pharmacology (early drug discovery and toxicology) and plant biology (response of wild or crop plants to environmental and agricultural substances). EU-OPENSCREEN supports all stages of a tool development project, including assay adaptation, high-throughput screening and chemical optimisation of the ‘hit’ compounds. All tool compounds and data will be made available to the scientific community. EU-OPENSCREEN integrates high-capacity screening platforms throughout Europe, which share a rationally selected compound collection comprising up to 300,000 (commercial and proprietary compounds collected from European chemists). By testing systematically this chemical collection in hundreds of assays originating from very different biological themes, the screening process generates enormous amounts of information about the biological activities of the substances and thereby steadily enriches our understanding of how and where they act. Springer Berlin Heidelberg 2014-07-31 /pmc/articles/PMC4182336/ /pubmed/25320643 http://dx.doi.org/10.1007/s12154-014-0118-9 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Notes Meiners, Torsten Stechmann, Bahne Frank, Ronald EU-OPENSCREEN—chemical tools for the study of plant biology and resistance mechanisms |
title | EU-OPENSCREEN—chemical tools for the study of plant biology and resistance mechanisms |
title_full | EU-OPENSCREEN—chemical tools for the study of plant biology and resistance mechanisms |
title_fullStr | EU-OPENSCREEN—chemical tools for the study of plant biology and resistance mechanisms |
title_full_unstemmed | EU-OPENSCREEN—chemical tools for the study of plant biology and resistance mechanisms |
title_short | EU-OPENSCREEN—chemical tools for the study of plant biology and resistance mechanisms |
title_sort | eu-openscreen—chemical tools for the study of plant biology and resistance mechanisms |
topic | Notes |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182336/ https://www.ncbi.nlm.nih.gov/pubmed/25320643 http://dx.doi.org/10.1007/s12154-014-0118-9 |
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