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Distribution of Serotypes, Vaccine Coverage, and Antimicrobial Susceptibility Pattern of Streptococcus Pneumoniae in Children Living in SAARC Countries: A Systematic Review

INTRODUCTION: Each SAARC nation falls in the zone of high incidence of pneumococcal disease but there is a paucity of literature estimating the burden of pneumococcal disease in this region. OBJECTIVE: To identify the prevalent serotypes causing invasive pneumococcal disease in children of SAARC cou...

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Detalles Bibliográficos
Autores principales: Jaiswal, Nishant, Singh, Meenu, Das, Rashmi Ranjan, Jindal, Ishita, Agarwal, Amit, Thumburu, Kiran Kumar, Kumar, Ajay, Chauhan, Anil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182530/
https://www.ncbi.nlm.nih.gov/pubmed/25268974
http://dx.doi.org/10.1371/journal.pone.0108617
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author Jaiswal, Nishant
Singh, Meenu
Das, Rashmi Ranjan
Jindal, Ishita
Agarwal, Amit
Thumburu, Kiran Kumar
Kumar, Ajay
Chauhan, Anil
author_facet Jaiswal, Nishant
Singh, Meenu
Das, Rashmi Ranjan
Jindal, Ishita
Agarwal, Amit
Thumburu, Kiran Kumar
Kumar, Ajay
Chauhan, Anil
author_sort Jaiswal, Nishant
collection PubMed
description INTRODUCTION: Each SAARC nation falls in the zone of high incidence of pneumococcal disease but there is a paucity of literature estimating the burden of pneumococcal disease in this region. OBJECTIVE: To identify the prevalent serotypes causing invasive pneumococcal disease in children of SAARC countries, to determine the coverage of these serotypes by the available vaccines, and to determine the antibiotic resistance pattern of Streptococcus pneumoniae. METHODS: We searched major electronic databases using a comprehensive search strategy, and additionally searched the bibliography of the included studies and retrieved articles till July 2014. Both community and hospital based observational studies which included children aged ≤12 years as/or part of the studied population in SAARC countries were included. RESULTS: A total of 17 studies were included in the final analysis. The period of surveillance varied from 12–96 months (median, 24 months). The most common serotypes country-wise were as follows: serotype 1 in Nepal; serotype 14 in Bangladesh and India; serotype 19F in Sri Lanka and Pakistan. PCV-10 was found to be suitable for countries like India, Nepal, Bangladesh, and Sri Lanka, whereas PCV-13 may be more suitable for Pakistan. An increasing trend of non-susceptibility to antibiotics was noted for co-trimoxazole, erythromycin and chloramphenicol, whereas an increasing trend of susceptibility was noted for penicillin. CONCLUSION: Due to paucity of recent data in majority of the SAARC countries, urgent large size prospective studies are needed to formulate recommendations for specific pneumococcal vaccine introduction and usage of antimicrobial agents in these regions.
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spelling pubmed-41825302014-10-07 Distribution of Serotypes, Vaccine Coverage, and Antimicrobial Susceptibility Pattern of Streptococcus Pneumoniae in Children Living in SAARC Countries: A Systematic Review Jaiswal, Nishant Singh, Meenu Das, Rashmi Ranjan Jindal, Ishita Agarwal, Amit Thumburu, Kiran Kumar Kumar, Ajay Chauhan, Anil PLoS One Research Article INTRODUCTION: Each SAARC nation falls in the zone of high incidence of pneumococcal disease but there is a paucity of literature estimating the burden of pneumococcal disease in this region. OBJECTIVE: To identify the prevalent serotypes causing invasive pneumococcal disease in children of SAARC countries, to determine the coverage of these serotypes by the available vaccines, and to determine the antibiotic resistance pattern of Streptococcus pneumoniae. METHODS: We searched major electronic databases using a comprehensive search strategy, and additionally searched the bibliography of the included studies and retrieved articles till July 2014. Both community and hospital based observational studies which included children aged ≤12 years as/or part of the studied population in SAARC countries were included. RESULTS: A total of 17 studies were included in the final analysis. The period of surveillance varied from 12–96 months (median, 24 months). The most common serotypes country-wise were as follows: serotype 1 in Nepal; serotype 14 in Bangladesh and India; serotype 19F in Sri Lanka and Pakistan. PCV-10 was found to be suitable for countries like India, Nepal, Bangladesh, and Sri Lanka, whereas PCV-13 may be more suitable for Pakistan. An increasing trend of non-susceptibility to antibiotics was noted for co-trimoxazole, erythromycin and chloramphenicol, whereas an increasing trend of susceptibility was noted for penicillin. CONCLUSION: Due to paucity of recent data in majority of the SAARC countries, urgent large size prospective studies are needed to formulate recommendations for specific pneumococcal vaccine introduction and usage of antimicrobial agents in these regions. Public Library of Science 2014-09-30 /pmc/articles/PMC4182530/ /pubmed/25268974 http://dx.doi.org/10.1371/journal.pone.0108617 Text en © 2014 Jaiswal et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Jaiswal, Nishant
Singh, Meenu
Das, Rashmi Ranjan
Jindal, Ishita
Agarwal, Amit
Thumburu, Kiran Kumar
Kumar, Ajay
Chauhan, Anil
Distribution of Serotypes, Vaccine Coverage, and Antimicrobial Susceptibility Pattern of Streptococcus Pneumoniae in Children Living in SAARC Countries: A Systematic Review
title Distribution of Serotypes, Vaccine Coverage, and Antimicrobial Susceptibility Pattern of Streptococcus Pneumoniae in Children Living in SAARC Countries: A Systematic Review
title_full Distribution of Serotypes, Vaccine Coverage, and Antimicrobial Susceptibility Pattern of Streptococcus Pneumoniae in Children Living in SAARC Countries: A Systematic Review
title_fullStr Distribution of Serotypes, Vaccine Coverage, and Antimicrobial Susceptibility Pattern of Streptococcus Pneumoniae in Children Living in SAARC Countries: A Systematic Review
title_full_unstemmed Distribution of Serotypes, Vaccine Coverage, and Antimicrobial Susceptibility Pattern of Streptococcus Pneumoniae in Children Living in SAARC Countries: A Systematic Review
title_short Distribution of Serotypes, Vaccine Coverage, and Antimicrobial Susceptibility Pattern of Streptococcus Pneumoniae in Children Living in SAARC Countries: A Systematic Review
title_sort distribution of serotypes, vaccine coverage, and antimicrobial susceptibility pattern of streptococcus pneumoniae in children living in saarc countries: a systematic review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182530/
https://www.ncbi.nlm.nih.gov/pubmed/25268974
http://dx.doi.org/10.1371/journal.pone.0108617
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